The extracellular matrix (ECM) consists of numerous macromolecules classified traditionally
into collagens, elastin, and microfibrillar proteins, proteoglycans including hyaluronan, and …

The stepwise progression from an early dysplastic lesion to full-blown metastatic malignancy
is associated with increases in genomic instability. Mitotic chromosomal instability—the …

2014-11-12 Assigned to IMMATICS BIOTECHNOLOGIES GMBH reassignment IMMATICS
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …

The endosomal sorting complexes required for transport (ESCRT) pathway was initially
defined in yeast genetic screens that identified the factors necessary to sort membrane …

DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of
protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic …

Tumor cell proliferation is frequently associated with genetic or epigenetic alterations in key
regulators of the cell cycle. Most known oncogenes and tumor suppressors target entry into …

Background Submucosal tumor, or submucosal lesion, is an umbrella term encompassing a
variety of non-neoplastic and neoplastic conditions (both benign and malignant). Their …

Gastrointestinal stromal tumors (GISTs) have a wide spectrum of biologic behavior ranging
from benign to malignant. Risk grading based on tumor size and mitotic counts has been …

Most GISTs require oncogenic activation of the KIT or PDGFRA receptor tyrosine kinase
proteins, and the genomic mechanisms of oncogene activation are heterogeneous. Notably …

In quantitative reverse transcription–polymerase chain reaction (qRT–PCR), normalization
using reference genes is a common useful approach, but the validation of suitable reference …