Why Do Dietary Flavonoids Have a Promising Effect as Enhancers of Anthracyclines? Hydroxyl Substituents, Bioavailability and Biological Activity

A Golonko, AJ Olichwier, R Swislocka… - International Journal of …, 2022 - mdpi.com
Anthracyclines currently play a key role in the treatment of many cancers, but the limiting
factor of their use is the widespread phenomenon of drug resistance and untargeted toxicity …

In silico approaches for drug repurposing in oncology: a scoping review

BRR Cavalcante, RD Freitas… - Frontiers in …, 2024 - frontiersin.org
Introduction: Cancer refers to a group of diseases characterized by the uncontrolled growth
and spread of abnormal cells in the body. Due to its complexity, it has been hard to find an …

Docking-based virtual screening and molecular dynamic studies to identify new RIOK2 inhibitors

M Ghandadi - Chemical Papers, 2023 - Springer
Since RIO (right open reading frame) family of kinases including RIOK1, RIOK2 and RIOK3
do not have any domain similar to typical kinases, they have called atypical kinase. Role of …

[HTML][HTML] 双氢青蒿素通过促进活性氧的产生增强鼻咽癌细胞对顺铂诱导凋亡的敏感性

从小凡, 陈腾, 李硕, 王媛媛, 周龙云… - Journal of Southern …, 2024 - pmc.ncbi.nlm.nih.gov
目的探究双氢青蒿素(DHA) 与顺铂(DDP) 联合应用对耐DDP 鼻咽癌细胞株HNE1/DDP
增殖抑制和促凋亡的作用及其机制. 方法CCK-8 法检测不同浓度DHA (0, 5, 10, 20, 40, 80,160 …

Dihydroartemisinin enhances sensitivity of nasopharyngeal carcinoma HNE1/DDP cells to cisplatin-induced apoptosis by promoting ROS production

X Cong, T Chen, S Li, Y Wang, L Zhou, X Li… - … Fang yi ke da xue xue …, 2024 - europepmc.org
Objective To investigate the effect of dihydroartemisinin (DHA) for enhancing the inhibitory
effect of cisplatin (DDP) on DDP-resistant nasopharyngeal carcinoma cell line HNE1/DDP …

A Nutraceutical Approach to Combating Chemoresistance in Acute Lymphoblastic Leukemia

O Idom - 2023 - search.proquest.com
Patients with acute lymphoblastic leukemia (ALL) often face relapse and death due to
chemoresistance to standard chemotherapy treatment. Based on studies that have …