Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety

MA Hannan, MA Rahman, AAM Sohag, MJ Uddin… - Nutrients, 2021 - mdpi.com
Mounting evidence support the potential benefits of functional foods or nutraceuticals for
human health and diseases. Black cumin (Nigella sativa L.), a highly valued nutraceutical …

Nigella sativa in controlling Type 2 diabetes, cardiovascular, and rheumatoid arthritis diseases: Molecular aspects

V Hadi, N Pahlavani, M Malekahmadi… - Journal of Research …, 2021 - journals.lww.com
Oxidative stress is an important factor in the etiology of several chronic diseases that include
cardiovascular disease (CVD), Type 2 diabetes (T2D), and rheumatoid arthritis (RA) …

Mineral oil: safety and use as placebo in REDUCE-IT and other clinical studies

B Olshansky, MK Chung, MJ Budoff… - European Heart …, 2020 - academic.oup.com
Mineral oil is often used as a clinical trial placebo. Pharmaceutical-grade mineral oil consists
of a mixture of saturated hydrocarbons, with a purity and chemical structure that differs …

Nigella sativa L. and Its Active Compound Thymoquinone in the Clinical Management of Diabetes: A Systematic Review

MF Mahomoodally, MZ Aumeeruddy… - International journal of …, 2022 - mdpi.com
Despite existing conventional hypoglycemic drugs to manage diabetes, their non-availability
and cost in low-income countries coupled with the associated side effects remain a major …

Development and characterization of a fucoidan-based nanoemulsion using Nigella sativa oil for improvement of anti-obesity activity of fucoxanthin in an obese rat …

N Oliyaei, N Tanideh, M Moosavi-Nasab… - International Journal of …, 2023 - Elsevier
The anti-obesity activity of encapsulated fucoxanthin in fucoidan-based nanoemulsion was
investigated. Then, high-fat diet (HFD) induced-obese rats were fed along with different …

Natural product heme oxygenase inducers as treatment for nonalcoholic fatty liver disease

DE Stec, TD Hinds Jr - International Journal of Molecular Sciences, 2020 - mdpi.com
Heme oxygenase (HO) is a critical component of the defense mechanism to a wide variety of
cellular stressors. HO induction affords cellular protection through the breakdown of toxic …

The effect of Nigella sativa (black seed) on biomarkers of inflammation and oxidative stress: an updated systematic review and meta-analysis of randomized …

Z Kavyani, V Musazadeh, S Golpour-Hamedani… - …, 2023 - Springer
Objective This study was conducted to assess the effect of Nigella sativa (N. sativa)
supplementation on inflammatory and oxidative markers among the adult population …

Black Cumin Seed (Nigella sativa) in Inflammatory Disorders: Therapeutic Potential and Promising Molecular Mechanisms

HK Rashwan, S Mahgoub, NZ Abuelezz… - Drugs and Drug …, 2023 - mdpi.com
Inflammation is an essential defense mechanism against harmful stimuli. However,
uncontrolled inflammatory mechanisms culminate in disturbed responses that contribute to …

Potential Pharmacological Applications of Nigella Seeds with a Focus on Nigella sativa and Its Constituents against Chronic Inflammatory Diseases: Progress and …

S Wahab, A Alsayari - Plants, 2023 - mdpi.com
The leading cause of death worldwide has been identified as chronic illnesses, according to
the World Health Organization (WHO). Chronic inflammatory conditions such as asthma …

Effect of saffron, black seed, and their main constituents on inflammatory cytokine response (mainly TNF-α) and oxidative stress status: An aspect on pharmacological …

Z Vafaeipour, M Ghasemzadeh Rahbardar… - Naunyn-Schmiedeberg's …, 2023 - Springer
Tumor necrosis factor-α (TNF-α), an inflammatory cytokine, is produced by monocytes and
macrophages. It is known as a'double-edged sword'because it is responsible for …