Antibiotic therapy has become increasingly ineffective against bacterial infections due to the
rise of resistance. In particular, ESKAPE pathogens (Enterococcus faecium, Staphylococcus …

Highlights•Endolysins are promising novel therapeutics for treatment of bacterial
infections.•Endolysins can target infections in different organs and tissues of the human …

At the end of a lytic bacteriophage replication cycle in Gram-positive bacteria, peptidoglycan-
degrading endolysins that cause explosive cell lysis of the host can also attack non-infected …

One of the possible solutions for the current antibiotic resistance crisis may be found in
(often bacteriophage-derived) peptidoglycan hydrolases. The first clinical trials of these …

There has been an increase in the search and application of new antimicrobial agents as
alternatives to use of chemical preservatives and antibiotic‐like compounds by the food …

The rapid increase in antibiotic resistance presents a dire situation necessitating the need
for alternative therapeutic agents. Among the current alternative therapies, phage therapy …

The emergence and evolution of antibiotic-resistant bacteria is considered a public health
concern. Salmonella is one of the most common pathogens that cause high mortality and …

Staphylococcus aureus is a major concern in human health care, mostly due to the
increasing prevalence of antibiotic resistance. Intracellular localization of S. aureus plays a …

Foodborne diseases are caused by food contaminated by pathogenic bacteria such as
Escherichia coli, Salmonella, Staphylococcus aureus, Listeria monocytogenes …

Polymeric prodrugs have been applied to control the delivery of various types of
therapeutics. Similarly, conjugation of peptide therapeutics to lipids has been used to …