Reactive oxygen species (ROS) are important in regulating normal cellular processes
whereas deregulated ROS leads to the development of a diseased state in humans …

Calcium is an important second messenger involved in intra-and extracellular signaling
cascades and plays an essential role in cell life and death decisions. The Ca 2+ signaling …

Bone marrow–derived stromal cells (BMSCs) protect against acute lung injury (ALI). To
determine the role of BMSC mitochondria in this protection, we airway-instilled mice first with …

Inflammation has been linked to multiple degenerative and acute diseases as well as the
aging process. Moreover, mitochondrial alterations play a central role in these processes …

There is increasing appreciation that mitochondria serve cellular functions beyond oxygen
sensing and energy production. Accordingly, it has become important to explore …

Mitochondria are one of the basic essential components for eukaryotic life survival. It is also
the source of respiratory ATP. Recently published studies have demonstrated that …

Intervertebral disc degeneration (IVDD) is commonly caused by imbalanced oxygen
metabolism-triggered inflammation. Overcoming the shortcomings of antioxidants in IVDD …

Hypercalcemia and hyperphosphatemia associate with an elevated risk of cardiovascular
events, yet the pathophysiological basis of this association is unclear. Disturbed mineral …

The common pathological manifestation of cystic fibrosis (CF) is associated with an
excessive lung inflammatory response characterized by interleukin-1β accumulation. CF …

High levels of reactive oxygen species (ROS) are observed in chronic human diseases such
as obesity, type 2 diabetes, atherosclerosis, and cardiovascular diseases. In addition to the …