Calreticulin (CALR) is an endoplasmic reticulum (ER)-resident protein involved in a
spectrum of cellular processes. In healthy cells, CALR operates as a chaperone and Ca2+ …

Endoplasmic reticulum (ER) calcium signaling is implicated in a myriad of coordinated
cellular processes. The ER calcium content is tightly regulated as it allows a favorable …

Background Somatic mutations in the Janus kinase 2 gene (JAK2) occur in many
myeloproliferative neoplasms, but the molecular pathogenesis of myeloproliferative …

Calreticulin (CALR) mutations were recently described in JAK2 and MPL unmutated primary
myelofibrosis (PMF) and essential thrombocythemia. In the current study, we compared the …

The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions
essential for cellular homeostasis, development, and stress responsiveness. In response to …

Mutations in the calreticulin gene (CALR) represented by deletions and insertions in exon 9
inducing a− 1/+ 2 frameshift are associated with a significant fraction of myeloproliferative …

Over the past decades, immunotherapy has demonstrated a prominent clinical efficacy in a
wide variety of human tumors. For many years, apoptosis has been considered a non …

Cancer progression is characterized by rapidly proliferating cancer cells that are in need of
increased protein synthesis. Therefore, enhanced endoplasmic reticulum (ER) activity is …

Recurrent somatic mutations of calreticulin (CALR) have been identified in patients
harboring myeloproliferative neoplasms; however, their role in tumorigenesis remains …

Endoplasmic reticulum (ER) stress is of considerable interest to plant biologists because it
occurs in plants subjected to adverse environmental conditions. ER stress responses …