Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

As one of the most abundant and well-studied epigenetic modifications, DNA methylation
plays an essential role in normal development and cellular biology. Global alterations to the …

Complex and dynamic networks of molecules are involved in human diseases. High-
throughput technologies enable omics studies interrogating thousands to millions of makers …

In many organisms, the methylation of cytosine in DNA has a key role in silencing'parasitic'
DNA elements, regulating transcription and establishing cellular identity. The recent …

The high level of 5-hydroxymethylcytosine (5hmC) present in neuronal genomes suggests
that mechanisms interpreting 5hmC in the CNS may differ from those present in embryonic …

Summary The study of 5-hydroxylmethylcytosines (5hmC) has been hampered by the lack of
a method to map it at single-base resolution on a genome-wide scale. Affinity purification …

Sperm and eggs carry distinctive epigenetic modifications that are adjusted by
reprogramming after fertilization. The paternal genome in a zygote undergoes active DNA …

Cytosine methylation is the major covalent modification of mammalian genomic DNA and
plays important roles in transcriptional regulation. The molecular mechanism underlying the …

Although at the genetic level cancer is caused by diverse mutations, epigenetic
modifications are characteristic of all cancers, from apparently normal precursor tissue to …