Major depression is a highly prevalent condition, affecting approximately 10% of the
population. 1 It is also a growing global problem, 2 and has been consistently associated …

BackgroundWhile depression is known to involve a disturbance of mood, movement and
cognition, its associated cognitive deficits are frequently viewed as simple epiphenomena of …

Context Depression and dementia are common in older adults and often co-occur, but it is
unclear whether depression is an etiologic risk factor for dementia. Objective To clarify the …

Objective: This review updates an earlier meta-analysis of the data on history of depression
as a risk factor for dementia. It also considers the available evidence on the hypotheses …

As the population ages, the economic and societal impacts of neurodegenerative and
neuropsychiatric disorders are expected to rise sharply. Like dementia, late-life depressive …

Background: White matter hyperintensities in MRI scans are age related but appear to be
more prevalent in depressed patients. They may be more pronounced in late onset …

Background: It is generally accepted that depression can be associated with significant
cognitive deficits and that depression can be comorbid with dementia. Objective: This review …

Background—The prevalence of white matter hyperintensities (WMHs) detected on cerebral
MRI is associated with hypertension, but it is not known whether blood pressure lowering …

Background Hippocampal volume reduction has been reported inconsistently in people with
major depression. Aims To evaluate the interrelationships between hippocampal volumes …

OBJECTIVES Alzheimer's disease and vascular dementia are associated with an increase
in changes in white matter on MRI. The aims were to investigate whether white matter …