Neural circuits underlying thirst and fluid homeostasis

CA Zimmerman, DE Leib, ZA Knight - Nature Reviews Neuroscience, 2017 - nature.com
Thirst motivates animals to find and consume water. More than 40 years ago, a set of
interconnected brain structures known as the lamina terminalis was shown to govern thirst …

Neural control and modulation of thirst, sodium appetite, and hunger

V Augustine, S Lee, Y Oka - Cell, 2020 - cell.com
The function of central appetite neurons is instructing animals to ingest specific nutrient
factors that the body needs. Emerging evidence suggests that individual appetite circuits for …

Genetic identification of a neural circuit that suppresses appetite

ME Carter, ME Soden, LS Zweifel, RD Palmiter - Nature, 2013 - nature.com
Appetite suppression occurs after a meal and in conditions when it is unfavourable to eat,
such as during illness or exposure to toxins. A brain region proposed to play a role in …

A craniofacial-specific monosynaptic circuit enables heightened affective pain

E Rodriguez, K Sakurai, J Xu, Y Chen, K Toda… - Nature …, 2017 - nature.com
Humans often rank craniofacial pain as more severe than body pain. Evidence suggests that
a stimulus of the same intensity induces stronger pain in the face than in the body. However …

A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution

S Nardone, R De Luca, A Zito, N Klymko… - Nature …, 2024 - nature.com
Abstract The “dorsal pons”, or “dorsal pontine tegmentum”(dPnTg), is part of the brainstem. It
is a complex, densely packed region whose nuclei are involved in regulating many vital …

The paraventricular hypothalamus regulates satiety and prevents obesity via two genetically distinct circuits

MM Li, JC Madara, JS Steger, MJ Krashes, N Balthasar… - Neuron, 2019 - cell.com
SIM1-expressing paraventricular hypothalamus (PVH) neurons are key regulators of energy
balance. Within the PVH SIM1 population, melanocortin-4 receptor-expressing (PVH MC4R) …

Molecular ontology of the parabrachial nucleus

S Karthik, D Huang, Y Delgado, JJ Laing… - Journal of …, 2022 - Wiley Online Library
Diverse neurons in the parabrachial nucleus (PB) communicate with widespread brain
regions. Despite evidence linking them to a variety of homeostatic functions, it remains …

Genetic identity of thermosensory relay neurons in the lateral parabrachial nucleus

JC Geerling, M Kim, CE Mahoney… - American Journal …, 2016 - journals.physiology.org
The parabrachial nucleus is important for thermoregulation because it relays skin
temperature information from the spinal cord to the hypothalamus. Prior work in rats …

Efferent projections of Vglut2, Foxp2, and Pdyn parabrachial neurons in mice

D Huang, FS Grady, L Peltekian… - Journal of Comparative …, 2021 - Wiley Online Library
The parabrachial nucleus (PB) is a complex structure located at the junction of the midbrain
and hindbrain. Its neurons have diverse genetic profiles and influence a variety of …

Kölliker–Fuse GABAergic and glutamatergic neurons project to distinct targets

JC Geerling, S Yokota, I Rukhadze… - Journal of …, 2017 - Wiley Online Library
The Kölliker‐Fuse nucleus (KF) is known primarily for its respiratory function as the
“pneumotaxic center” or “pontine respiratory group.” Considered part of the parabrachial …