Prospects for developing an hepatitis C virus E1E2‐based nanoparticle vaccine

EA Toth, AK Andrianov… - Reviews in Medical …, 2023 - Wiley Online Library
Globally, more than 58 million people are chronically infected with Hepatitis C virus (HCV)
with 1.5 million new infections occurring each year. An effective vaccine for HCV is therefore …

Polyphosphazene immunoadjuvants: Historical perspective and recent advances

AK Andrianov, R Langer - Journal of Controlled Release, 2021 - Elsevier
The development of successful vaccines has been increasingly reliant on the use of
immunoadjuvants-additives, which can enhance and modulate immune responses to …

Immunologically effective biomaterials-enhanced vaccines against infection of pathogenic microorganisms

Q Wei, S Liu, X Huang, H Xin, J Ding - Biosafety and health, 2023 - mednexus.org
Infectious diseases are severe public health events that threaten global health. Prophylactic
vaccines have been considered as the most effective strategy to train the immune system to …

Separation and characterization of biomacromolecules, bionanoparticles, and biomicroparticles using flow field-flow fractionation: Current applications and prospects

Z Wu, W Zhao, Y Yin, Y Wei, Y Liu, N Zhu, Z Tan… - TrAC Trends in …, 2023 - Elsevier
Flow field-flow fractionation (FlFFF) is a gentle technique that does not require a stationary
phase and allows for the non-destructive isolation/separation of biomacromolecules and …

Immunopotentiating Polyphosphazene Delivery Systems: Supramolecular Self-Assembly and Stability in the Presence of Plasma Proteins

A Marin, SH Kethanapalli… - Molecular …, 2024 - ACS Publications
Studies on the biological performance of nanomedicines have been increasingly focused on
the paradigm shifting role of the protein corona, which is imminently formed once the …

[HTML][HTML] Asymmetric flow field-flow fractionation as a multifunctional technique for the characterization of polymeric nanocarriers

F Quattrini, G Berrecoso, J Crecente-Campo… - Drug delivery and …, 2021 - Springer
The importance of polymeric nanocarriers in the field of drug delivery is ever-increasing, and
the accurate characterization of their properties is paramount to understand and predict their …

Polyphosphazene: a new adjuvant platform for cocaine vaccine development

M Lin, A Marin, B Ellis, LM Eubanks… - Molecular …, 2022 - ACS Publications
Cocaine is a highly addictive drug that has seen a steady uptrend causing severe health
problems worldwide. Currently, there are no approved therapeutics for treating cocaine use …

[HTML][HTML] Polyphosphazene-based biomaterials for biomedical applications

GW Jin, NS Rejinold, JH Choy - International Journal of Molecular …, 2022 - mdpi.com
Recently, synthetic polymers have attracted great interest in the field of biomedical science.
Among these, polyphosphazenes (PPZs) are regarded as one of the most promising …

[HTML][HTML] Supramolecular protein-polyelectrolyte assembly at near physiological conditions—water proton NMR, ITC, and DLS study

A Marin, MB Taraban, V Patel, YB Yu, AK Andrianov - Molecules, 2022 - mdpi.com
The in vivo potency of polyphosphazene immunoadjuvants is inherently linked to the ability
of these ionic macromolecules to assemble with antigenic proteins in aqueous solutions and …

Degradable Bottlebrush Polypeptides and the Impact of their Architecture on Cell Uptake, Pharmacokinetics, and Biodistribution In Vivo

P Strasser, B Montsch, S Weiss, H Sami, C Kugler… - Small, 2023 - Wiley Online Library
Bottlebrush polymers are highly promising as unimolecular nanomedicines due to their
unique control over the critical parameters of size, shape and chemical function. However …