The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation
AP Halestrap, NT PRICE - Biochemical Journal, 1999 - portlandpress.com
Monocarboxylates such as lactate and pyruvate play a central role in cellular metabolism
and metabolic communication between tissues. Essential to these roles is their rapid …
and metabolic communication between tissues. Essential to these roles is their rapid …
Structural and functional regulation of lactate dehydrogenase-A in cancer
MR Woodford, VZ Chen, SJ Backe… - Future Medicinal …, 2020 - Taylor & Francis
Dysregulated metabolism is one of the hallmarks of cancer. Under normal physiological
conditions, ATP is primarily generated by oxidative phosphorylation. Cancers commonly …
conditions, ATP is primarily generated by oxidative phosphorylation. Cancers commonly …
Roles of key active-site residues in flavocytochrome P450 BM3
MA Noble, CS Miles, SK Chapman… - Biochemical …, 1999 - portlandpress.com
The effects of mutation of key active-site residues (Arg-47, Tyr-51, Phe-42 and Phe-87) in
Bacillus megaterium flavocytochrome P450 BM3 were investigated. Kinetic studies on the …
Bacillus megaterium flavocytochrome P450 BM3 were investigated. Kinetic studies on the …
Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past
TN PRICE, NV JACKSON… - Biochemical …, 1998 - portlandpress.com
Measurement of monocarboxylate transport kinetics in a range of cell types has provided
strong circumstantial evidence for a family of monocarboxylate transporters (MCTs). Two …
strong circumstantial evidence for a family of monocarboxylate transporters (MCTs). Two …
D-lactate dehydrogenase is a member of the D-isomer-specific 2-hydroxyacid dehydrogenase family. Cloning, sequencing, and expression in Escherichia coli of the D …
H Taguchi, T Ohta - Journal of Biological Chemistry, 1991 - ASBMB
The gene encoding D-lactate dehydrogenase (D-lactate: NAD+ oxidoreductase, EC 1.1.
1.28) of Lactobacillus plantarum has been sequenced, and expressed in Escherichia coli …
1.28) of Lactobacillus plantarum has been sequenced, and expressed in Escherichia coli …
Design and synthesis of new enzymes based on the lactate dehydrogenase framework
CR Dunn, HM Wilks, DJ Halsall… - … of the Royal …, 1991 - royalsocietypublishing.org
Analysis of the mechanism and structure of lactate dehydrogenases is summarized in a map
of the catalytic pathway. Chemical probes, single tryptophan residues inserted at specific …
of the catalytic pathway. Chemical probes, single tryptophan residues inserted at specific …
The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane …
C Manoharan, C Manoharan, MC Wilson… - Molecular membrane …, 2006 - Taylor & Francis
Monocarboxylate transporters MCT1-MCT4 require basigin (CD147) or embigin (gp70),
ancillary proteins with a glutamate residue in their single transmembrane (TM) domain, for …
ancillary proteins with a glutamate residue in their single transmembrane (TM) domain, for …
An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases
JI Boucher, JR Jacobowitz, BC Beckett, S Classen… - Elife, 2014 - elifesciences.org
Malate and lactate dehydrogenases (MDH and LDH) are homologous, core metabolic
enzymes that share a fold and catalytic mechanism yet possess strict specificity for their …
enzymes that share a fold and catalytic mechanism yet possess strict specificity for their …
Stochastic roadmap simulation: An efficient representation and algorithm for analyzing molecular motion
Classic techniques for simulating molecular motion, such as the Monte Carlo and molecular
dynamics methods, generate individual motion pathways one at a time and spend most of …
dynamics methods, generate individual motion pathways one at a time and spend most of …
[HTML][HTML] Lactate dehydrogenase from the hyperthermophilic bacterium Thermotoga maritima: the crystal structure at 2.1 Å resolution reveals strategies for intrinsic …
G Auerbach, R Ostendorp, L Prade, I Korndörfer… - Structure, 1998 - cell.com
Abstract Background: L (+)-Lactate dehydrogenase (LDH) catalyzes the last step in
anaerobic glycolysis, the conversion of pyruvate to lactate, with the concomitant oxidation of …
anaerobic glycolysis, the conversion of pyruvate to lactate, with the concomitant oxidation of …