Colon cancer affects both men and women and is the world's second most significant cause
of cancer-related mortality. Colon cancer death rates have risen worldwide due to the …

Minocycline is a second‐generation, semi‐synthetic tetracycline that has been in therapeutic
use for over 30 years because of its antibiotic properties against both gram‐positive and …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

Chronic pain is a frequent component of many neurological disorders, affecting 20–40% of
patients for many primary neurological diseases. These diseases result from a wide range of …

Minocycline is a semi-synthetic, second-generation tetracycline analog which is effectively
crossing the blood–brain barrier, effective against gram-positive and-negative infections. In …

The capacity of minocycline to alleviate disease for several neurological disorders in
animals is increasingly being recognised. Indeed, that one drug alone can attenuate the …

Microglial activation may play a role in the pathogenesis of Huntington's disease (HD).
Using 11C-(R)-PK11195 (PK) positron emission tomography (PET), we investigated …

Huntington's disease (HD) is a devastating autosomal dominant neurodegenerative disease
caused by a CAG trinucleotide repeat expansion encoding an abnormally long …

The lack of robust treatment options available for neurodegenerative diseases, stroke, and
central nervous system (CNS) trauma, all of which often involve both inflammation and …

Huntington's disease is associated with a reactive microglial response and consequent
inflammation. To address the role of these cells in disease pathogenesis, we depleted …