The Warburg effect explained: integration of enhanced glycolysis with heterogeneous mitochondria to promote cancer cell proliferation
L Alberghina - International Journal of Molecular Sciences, 2023 - mdpi.com
The Warburg effect is the long-standing riddle of cancer biology. How does aerobic
glycolysis, inefficient in producing ATP, confer a growth advantage to cancer cells? A new …
glycolysis, inefficient in producing ATP, confer a growth advantage to cancer cells? A new …
Breast cancers as ecosystems: a metabolic perspective
F Martino, M Lupi, E Giraudo, L Lanzetti - Cellular and Molecular Life …, 2023 - Springer
Breast cancer (BC) is the most frequently diagnosed cancer and one of the major causes of
cancer death. Despite enormous progress in its management, both from the therapeutic and …
cancer death. Despite enormous progress in its management, both from the therapeutic and …
Multivariate analysis of metabolic state vulnerabilities across diverse cancer contexts reveals synthetically lethal associations
C Abecunas, AD Kidd, Y Jiang, H Zong… - Cell reports, 2024 - cell.com
Targeting the distinct metabolic needs of tumor cells has recently emerged as a promising
strategy for cancer therapy. The heterogeneous, context-dependent nature of cancer cell …
strategy for cancer therapy. The heterogeneous, context-dependent nature of cancer cell …
Meta‐analysis of the prevalence of attention‐deficit hyperactivity disorder in prison: A comment on Fazel and Favril (2024) and reanalysis of the data
S Baggio, O Efthimiou - Criminal Behaviour and Mental Health, 2024 - Wiley Online Library
Abstract Background Fazel and Favril presented a reanalysis of our previously published
systematic review and meta‐analysis on the prevalence of attention deficit hyperactivity …
systematic review and meta‐analysis on the prevalence of attention deficit hyperactivity …
Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia
ZBTB7A belongs to a small family of transcription factors having three members in humans
(7A, 7B, and 7C). They share a BTB/POZ protein interaction domain at the amino end and a …
(7A, 7B, and 7C). They share a BTB/POZ protein interaction domain at the amino end and a …
Heterogeneity of the cancer cell line metabolic landscape
D Shorthouse, J Bradley, SE Critchlow… - Molecular Systems …, 2022 - embopress.org
The unravelling of the complexity of cellular metabolism is in its infancy. Cancer‐associated
genetic alterations may result in changes to cellular metabolism that aid in understanding …
genetic alterations may result in changes to cellular metabolism that aid in understanding …
Divergent metabolomic signatures of TGFβ2 and TNFα in the induction of retinal epithelial-mesenchymal transition
Epithelial-mesenchymal transition (EMT) is a dedifferentiation program in which polarized,
differentiated epithelial cells lose their cell-cell adhesions and transform into matrix …
differentiated epithelial cells lose their cell-cell adhesions and transform into matrix …
MsQuality: an interoperable open-source package for the calculation of standardized quality metrics of mass spectrometry data
Motivation Multiple factors can impact accuracy and reproducibility of mass spectrometry
data. There is a need to integrate quality assessment and control into data analytic …
data. There is a need to integrate quality assessment and control into data analytic …
[PDF][PDF] Regularized adversarial learning for normalization of multi-batch untargeted metabolomics data
A Dmitrenko, M Reid, N Zamboni - Bioinformatics, 2023 - academic.oup.com
Motivation Untargeted metabolomics by mass spectrometry is the method of choice for
unbiased analysis of molecules in complex samples of biological, clinical or environmental …
unbiased analysis of molecules in complex samples of biological, clinical or environmental …
[HTML][HTML] Mitochondrial dysfunction results in enhanced adrenal androgen production in H295R cells
D Mathis, T du Toit, EM Altinkilic, D Stojkov… - The journal of steroid …, 2024 - Elsevier
The role of mitochondria in steroidogenesis is well established. However, the specific effects
of mitochondrial dysfunction on androgen synthesis are not fully understood. In this study …
of mitochondrial dysfunction on androgen synthesis are not fully understood. In this study …