Antivenoms for the treatment of snakebite envenomings: the road ahead

JM Gutiérrez, G León, T Burnouf - Biologicals, 2011 - Elsevier
The parenteral administration of antivenoms is the cornerstone of snakebite envenoming
therapy. Efforts are made to ensure that antivenoms of adequate efficacy and safety are …

[HTML][HTML] Innovative immunization strategies for antivenom development

E Bermúdez-Méndez, A Fuglsang-Madsen, S Føns… - Toxins, 2018 - mdpi.com
Snakes, scorpions, and spiders are venomous animals that pose a threat to human health,
and severe envenomings from the bites or stings of these animals must be treated with …

Immune response towards snake venoms

G León, L Sánchez, A Hernández… - … & Allergy-Drug …, 2011 - ingentaconnect.com
The immune response involves a complex repertoire of innate and adaptive responses to
foreign agents in the organism. The present review focuses on the immune response to …

Phospholipase A2 myotoxins from Bothrops snake venoms: structure-function relationship

AM Soares, MRM Fontes… - Current Organic Chemistry, 2004 - ingentaconnect.com
Phospholipases A2 constitute the major components from Bothrops snake venoms and have
been extensively investigated not only because they are relatively very abundant in these …

[PDF][PDF] Pathophysiological and pharmacological effects of snake venom components: molecular targets

L Fatima, C Fatah - J Clin Toxicol, 2014 - researchgate.net
Snake venoms are a mixture of hydrolases which produce complex pathogenesis such as
bleeding, dermo/myonecrosis, inflammation and coagulation disorders. The toxicity of …

[HTML][HTML] Advances in irradiated livestock vaccine research and production addressing the unmet needs for farmers and veterinary services in FAO/IAEA member states

H Unger, RT Kangethe, F Liaqat, GJ Viljoen - Frontiers in Immunology, 2022 - frontiersin.org
The Animal Production and Health section (APH) of the Joint FAO/IAEA Centre of Nuclear
Techniques in Food and Agriculture at the International Atomic Energy Agency has over the …

Pro and antiinflammatory properties of toxins from animal venoms

SHP Farsky, E Antunes… - Current Drug Targets …, 2005 - ingentaconnect.com
Accidents evoked by venomous animals are common in tropical regions. In Brazil,
envenomation evoked by snakes, spiders and scorpions are an important public health …

Evaluation of the effect of gamma rays on the venom of Vipera lebetina by biochemical study

N Bennacef-Heffar… - Canadian journal of …, 2003 - cdnsciencepub.com
Snake bites represent a serious public health problem in many areas of the world. In Algeria,
two widespread snakes are Vipera lebetina and Cerastes cerastes. Vipera lebetina venom …

Pathophysiological effects of Cerastes cerastes and Vipera lebetina venoms: Immunoneutralization using anti-native and anti-60Co irradiated venoms

S Boumaiza, H Oussedik-Oumehdi, F Laraba-Djebari - Biologicals, 2016 - Elsevier
Cerastes cerastes and Vipera lebetina are the most medically important vipers in Algeria.
Their bite induces several pathological effects on victims of accidental envenomation. In this …

Potential low-impact immunogen for the production of anti-bothropic serum: Bothrops alternatus venom treated with Na2EDTA

GL Lopez, A Van de Velde, D Hernández, S Bustillo… - Toxicon, 2024 - Elsevier
This study proposes an alternative method using Na 2 EDTA to neutralize B. alternatus
venom and using it as an immunogen from the start of inoculation to minimize side effects …