With the spectacular advancement of NMR techniques and the flourishing of fluorine
chemistry allowing the synthesis of various fluorinated molecules, 19F NMR represents a …

Over the last several decades, significant technical and experimental advances have made
quantitative nuclear magnetic resonance (qNMR) a valuable analytical tool for quantitative …

Ligand-based fluorine NMR screening has gained popularity in drug discovery projects
during the past decade and has become a powerful methodology to produce high quality …

Fluorine is widely used in the lead optimization phase of drug discovery projects. More
recently, fluorine NMR-based spectroscopy has emerged as a versatile, reliable and efficient …

Fragment screening performed with 19F NMR spectroscopy is becoming increasingly
popular in drug discovery projects. With this approach, libraries of fluorinated fragments are …

The substrate-or cofactor-based fluorine NMR screening, also known as n-FABS (n fluorine
atoms for biochemical screening), represents a powerful method for performing a direct …

Nuclear magnetic resonance (NMR)-based screening has been recognized as a powerful
approach for the identification and characterization of molecules interacting with …

The technical and practical aspects of 19F NMR‐based screening against a macromolecular
target are analyzed in detail. A novel method utilizing the relaxation of 19F homonuclear …

Despite the recognized importance of membrane proteins as pharmaceutical targets, the
reliable identification of fragment hits that are able to bind these proteins is still a major …

Bioactive peptides derived from foods provide physiological health benefits beyond nutrition.
This study focused on profiling small peptide inhibitors against two key serine proteases …