Oxidative stress, a cytopathic outcome of excessive generation of ROS and the repression of
antioxidant defense system for ROS elimination, is involved in the pathogenesis of multiple …

The numerous beneficial health outcomes associated with the use of metformin to treat
patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals …

Neurodegenerative diseases are strongly age-related and currently cannot be cured, with a
surge of patient numbers in the coming decades in view of the emerging worldwide ageing …

Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

Diabetes mellitus (DM) is one of the most prevalent chronic diseases worldwide. High
morbidity and mortality caused by DM are closely linked to its complications in multiple …

Aging has been targeted by genetic and dietary manipulation and by drugs in order to
increase lifespan and health span in numerous models. Metformin, which has demonstrated …

This systematic review investigated whether the insulin sensitiser metformin has a
geroprotective effect in humans. Pubmed and Embase were searched along with databases …

Metformin is the most commonly prescribed drug for type 2 diabetes mellitus. In recent years,
in addition to glucose lowering, several studies have presented evidence suggesting some …

Mitochondrial dysfunction is a central aspect of aging and neurodegenerative diseases,
including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and …

Hyperglycemia and insulin resistance are key players in the development of atherosclerosis
and its complications. A large body of evidence suggest that metabolic abnormalities cause …