Clostridium difficile infection

WK Smits, D Lyras, DB Lacy, MH Wilcox… - Nature reviews Disease …, 2016 - nature.com
Infection of the colon with the Gram-positive bacterium Clostridium difficile is potentially life
threatening, especially in elderly people and in patients who have dysbiosis of the gut …

Understanding Clostridium difficile colonization

MJT Crobach, JJ Vernon, VG Loo… - Clinical microbiology …, 2018 - Am Soc Microbiol
Clostridium difficile is the main causative agent of antibiotic-associated and health care-
associated infective diarrhea. Recently, there has been growing interest in alternative …

Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for …

LC McDonald, DN Gerding, S Johnson… - Clinical infectious …, 2018 - academic.oup.com
Triptolide (TP), a traditional Chinese medicine, has been reported to be effective in the
treatment of autoimmune diseases and exerting antineoplastic activity in several human …

Overdiagnosis of Clostridium difficile infection in the molecular test era

CR Polage, CE Gyorke, MA Kennedy… - JAMA internal …, 2015 - jamanetwork.com
Importance Clostridium difficileis a major cause of health care–associated infection, but
disagreement between diagnostic tests is an ongoing barrier to clinical decision making and …

[HTML][HTML] European Society of Clinical Microbiology and Infectious Diseases: update of the diagnostic guidance document for Clostridium difficile infection

MJT Crobach, T Planche, C Eckert, F Barbut… - Clinical microbiology …, 2016 - Elsevier
Abstract In 2009 the first European Society of Clinical Microbiology and Infectious Diseases
(ESCMID) guideline for diagnosing Clostridium difficile infection (CDI) was launched. Since …

Guidelines for diagnosis, treatment, and prevention ofclostridium difficileInfections

CM Surawicz, LJ Brandt, DG Binion… - Official journal of the …, 2013 - journals.lww.com
Clostridium difficileinfection (CDI) is a leading cause of hospital-associated gastrointestinal
illness and places a high burden on our health-care system. Patients with CDI typically have …

SER-109, an Investigational Microbiome Drug to Reduce Recurrence After Clostridioides difficile Infection: Lessons Learned From a Phase 2 Trial

BH McGovern, CB Ford, MR Henn… - Clinical Infectious …, 2021 - academic.oup.com
Abstract Background Recurrent Clostridioides difficile infection (rCDI) is associated with loss
of microbial diversity and microbe-derived secondary bile acids, which inhibit C. difficile …

Underdiagnosis of Clostridium difficile across Europe: the European, multicentre, prospective, biannual, point-prevalence study of Clostridium difficile infection in …

KA Davies, CM Longshaw, GL Davis… - The Lancet infectious …, 2014 - thelancet.com
Background Variations in testing for Clostridium difficile infection can hinder patients' care,
increase the risk of transmission, and skew epidemiological data. We aimed to measure the …

Diagnosis of Clostridium difficile infection: an ongoing conundrum for clinicians and for clinical laboratories

BD Carey-Ann, KC Carroll - Clinical microbiology reviews, 2013 - Am Soc Microbiol
Clostridium difficile is a formidable nosocomial and community-acquired pathogen, causing
clinical presentations ranging from asymptomatic colonization to self-limiting diarrhea to …

[HTML][HTML] Differences in outcome according to Clostridium difficile testing method: a prospective multicentre diagnostic validation study of C difficile infection

TD Planche, KA Davies, PG Coen… - The Lancet infectious …, 2013 - thelancet.com
Summary Background Diagnosis of Clostridium difficile infection is controversial because of
many laboratory methods, compounded by two reference methods. Cytotoxigenic culture …