Currently, two main cell culture models predominate pluripotent stem cell research:
embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Thanks to their …

Dramatic nuclear reorganization occurs during early development to convert terminally
differentiated gametes to a totipotent zygote, which then gives rise to an embryo. Aberrant …

In mice, transcription initiates at the mid-one-cell stage and transcriptional activity
dramatically increases during the two-cell stage, a process called zygotic gene activation …

The shift from maternal to embryonic control is a critical developmental milestone in
preimplantation development. Widespread transcriptomic and epigenetic remodeling …

The zygotic genome is transcriptionally silent immediately after fertilization. In mice, initial
activation of the zygotic genome occurs in the middle of the one-cell stage. At the mid-to-late …

Nucleosome positioning can alter the accessibility of DNA-binding proteins to their cognate
DNA elements, and thus its precise control is essential for cell identity and function …

The majority of our genome is composed of repeated DNA sequences that assemble into
heterochromatin, a highly compacted structure that constrains their mutational potential …

How histone modifications regulate changes in gene expression during preimplantation
development in any species remains poorly understood. Using CUT&Tag to overcome …

Round spermatid injection (ROSI) results in a lower birth rate than intracytoplasmic sperm
injection, which has hampered its clinical application. Inefficient development of ROSI …

Pre-implantation embryo development encompasses several key developmental events,
especially the activation of zygotic genome activation (ZGA)-related genes. Endogenous …