[HTML][HTML] Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies

R Bhattacharjee, SS Das, SS Biswal, A Nath… - Critical reviews in …, 2022 - Elsevier
Purpose Cervical cancer (CC), one of the major causes of death of women throughout the
world is primarily caused due to Human Papilloma Virus (HPV) 16 and 18. The early region …

[HTML][HTML] Cyclooxygenase-1 (COX-1) and COX-1 inhibitors in cancer: A review of oncology and medicinal chemistry literature

A Pannunzio, M Coluccia - Pharmaceuticals, 2018 - mdpi.com
Prostaglandins and thromboxane are lipid signaling molecules deriving from arachidonic
acid by the action of the cyclooxygenase isoenzymes COX-1 and COX-2. The role of …

[HTML][HTML] COX-2-PGE2-EPs in gynecological cancers

Y Ye, X Wang, U Jeschke, V von Schönfeldt - Archives of gynecology and …, 2020 - Springer
Purpose Nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors
(COXibs) inhibit the progression of endometrial cancer, ovarian cancer and cervical cancer …

[HTML][HTML] Piperine reduces neoplastic progression in cervical cancer cells by downregulating the cyclooxygenase 2 pathway

LP Cardoso, SO de Sousa, JP Gusson-Zanetoni… - Pharmaceuticals, 2023 - mdpi.com
Cervical cancer is the fourth-most common type of cancer in the world that causes death in
women. It is mainly caused by persistent infection by human papillomavirus (HPV) that …

[HTML][HTML] Identification of a ferroptosis-related prognostic gene PTGS2 based on risk modeling and immune microenvironment of early-stage cervical cancer

C Zou, F Xu, J Shen, S Xu - Journal of oncology, 2022 - hindawi.com
Background. Cervical cancer (CC) has long been a concern, as a gynecological cancer type
of high-risk. At present, there are few studies on the early detection of CC at the genetic …

Advances in molecular mechanism of HPV16 E5 oncoprotein carcinogenesis

B Chen, L Zhao, R Yang, T Xu - Archives of Biochemistry and Biophysics, 2023 - Elsevier
For a considerable duration, cervical cancer has posed a significant risk to the well-being
and survival of women. The emergence and progression of cervical cancer have garnered …

Prostaglandin F2α-PTGFR signaling promotes proliferation of endometrial epithelial cells of cattle through cell cycle regulation

C Fu, W Mao, R Gao, Y Deng, L Gao, J Wu… - Animal reproduction …, 2020 - Elsevier
There is production of prostaglandin F 2α (PGF 2α) and there is PGF 2α receptor (PTGFR)
mRNA transcript in endometrial epithelial cells of cattle. The aims of the present study were …

Cleavage and polyadenylation specific factor 4 targets NF-κB/cyclooxygenase-2 signaling to promote lung cancer growth and progression

C Yi, Y Wang, C Zhang, Y Xuan, S Zhao, T Liu, W Li… - Cancer letters, 2016 - Elsevier
Abstract Overexpression of cyclooxygenase 2 (COX-2) is frequently found in early and
advanced lung cancers. However, the precise regulatory mechanism of COX-2 in lung …

[HTML][HTML] Amiodarone promotes cancer cell death through elevated truncated SRSF3 and downregulation of miR-224

YL Chang, ST Liu, YW Wang, WS Lin, SM Huang - Oncotarget, 2018 - ncbi.nlm.nih.gov
Amiodarone is a widely used class III antiarrhythmic agent which prolongs the action
potential and refractory period by blockage of several types of myocardial potassium …

[HTML][HTML] Celecoxib-mediated activation of endoplasmic reticulum stress induces de novo ceramide biosynthesis and apoptosis in hepatoma HepG2 cells

HJ Maeng, JH Song, GT Kim, YJ Song, K Lee… - BMB …, 2017 - ncbi.nlm.nih.gov
Ceramides are the major sphingolipid metabolites involved in cell survival and apoptosis.
When HepG2 hepatoma cells were treated with celecoxib, the expression of the genes in de …