The angiotensin-converting enzyme 2 (ACE2) is the receptor for the three coronaviruses
HCoV-NL63, SARS-CoV, and SARS-CoV-2. ACE2 is involved in the regulation of the renin …

The three-dimensional organization of chromatin contributes to transcriptional control, but
information about native chromatin distribution is limited. Imaging chromatin in live …

Animal genomes are organized into topologically associated domains (TADs). TADs are
thought to contribute to gene regulation by facilitating enhancer-promoter (EP) contacts …

The chromatin of the human genome was analyzed at three DNA size levels. At the first,
compartment level, two “gene spaces” were found many years ago: A GC-rich, gene-rich …

Chromosomal rearrangements have been shown to alter genome organization,
consequently having an impact on gene expression. Studies on certain types of leukemia …

Condensins are molecular motors that compact DNA via linear translocation. In
Caenorhabditis elegans, the X-chromosome harbors a specialized condensin that …

Polycomb group (PcG) proteins modulate higher-order genome folding and play a critical
role in silencing transcription during development. It is commonly proposed that PcG …

Condensins are molecular motors that compact DNA for chromosome segregation and gene
regulation. In vitro experiments have begun to elucidate the mechanics of condensin …

The genome contains numerous regulatory elements that may undergo complex interactions
and contribute to the establishment, maintenance, and change of cellular identity. Three …

Regulation of gene expression hinges on the interplay between enhancers and promoters,
traditionally explored through pairwise analyses. Recent advancements in mapping genome …