System Xc /GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy

FJ Li, HZ Long, ZW Zhou, HY Luo, SG Xu… - Frontiers in …, 2022 - frontiersin.org
The activation of ferroptosis is a new effective way to treat drug-resistant solid tumors.
Ferroptosis is an iron-mediated form of cell death caused by the accumulation of lipid …

Ferroptosis in cancer therapy: a novel approach to reversing drug resistance

C Zhang, X Liu, S Jin, Y Chen, R Guo - Molecular cancer, 2022 - Springer
Ferroptosis is an intracellular iron-dependent form of cell death that is distinct from
apoptosis, necrosis, and autophagy. Extensive studies suggest that ferroptosis plays a …

Loss of cancer-associated fibroblast-derived exosomal DACT3-AS1 promotes malignant transformation and ferroptosis-mediated oxaliplatin resistance in gastric …

X Qu, B Liu, L Wang, L Liu, W Zhao, C Liu, J Ding… - Drug Resistance …, 2023 - Elsevier
Abstract Aims Long non-coding RNAs (lncRNAs), as one of the components of exosomes
derived from cancer-associated fibroblasts (CAFs), exhibit a crucial role in the pathogenesis …

Role of ferroptosis on tumor progression and immunotherapy

D Gong, M Chen, Y Wang, J Shi, Y Hou - Cell death discovery, 2022 - nature.com
Ferroptosis is triggered by intracellular iron leading to accumulation of lipid peroxidation
consequent promotion of cell death. Cancer cell exhibits ability to evade ferroptosis by …

Ferroptosis, necroptosis, and pyroptosis in gastrointestinal cancers: the chief culprits of tumor progression and drug resistance

X Zhu, S Li - Advanced Science, 2023 - Wiley Online Library
In recent years, the incidence of gastrointestinal cancers is increasing, particularly in the
younger population. Effective treatment is crucial for improving patients' survival outcomes …

Drug resistance in colorectal cancer: from mechanism to clinic

Q Wang, X Shen, G Chen, J Du - Cancers, 2022 - mdpi.com
Simple Summary Chemotherapy, radiotherapy and molecularly targeted therapy could
improve the prognosis of colorectal cancer (CRC) patients. Recently, immunotherapy …

[HTML][HTML] Ferroptosis in colorectal cancer: Potential mechanisms and effective therapeutic targets

Y Wang, Z Zhang, W Sun, J Zhang, Q Xu, X Zhou… - Biomedicine & …, 2022 - Elsevier
Colorectal cancer (CRC) is a common malignant tumor characterized by unchecked division
and survival of abnormal cells in the colon or rectum with high morbidity and mortality …

The role of ferroptosis in lung cancer

S Wu, C Zhu, D Tang, QP Dou, J Shen, X Chen - Biomarker research, 2021 - Springer
Lung cancer is one of the most common cancers in the world. Although medical treatment
has made impressive progress in recent years, it is still one of the leading causes of cancer …

Zooming in and out of ferroptosis in human disease

X Wang, Y Zhou, J Min, F Wang - Frontiers of Medicine, 2023 - Springer
Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid
peroxidation. In the past decade, it has been implicated in the pathogenesis of various …

Ferroptosis in gastrointestinal cancer: from mechanisms to implications

R Zhang, R Kang, D Tang - Cancer Letters, 2023 - Elsevier
Ferroptosis is a form of regulated cell death that is initiated by excessive lipid peroxidation
that results in plasma membrane damage and the release of damage-associated molecular …