[HTML][HTML] Toward an effective Staphylococcus vaccine: why have candidates failed and what is the next step?
S. aureus is a leading cause of infection and a major driver of antibiotic resistance.
Appropriately, it consistently ranks on the CDC list of 'THREAT'pathogens that are in dire …
Appropriately, it consistently ranks on the CDC list of 'THREAT'pathogens that are in dire …
[HTML][HTML] Linking S. aureus Immune Evasion Mechanisms to Staphylococcal Vaccine Failures
IA Hajam, GY Liu - Antibiotics, 2024 - mdpi.com
Vaccination arguably remains the only long-term strategy to limit the spread of S. aureus
infections and its related antibiotic resistance. To date, however, all staphylococcal vaccines …
infections and its related antibiotic resistance. To date, however, all staphylococcal vaccines …
[HTML][HTML] The characteristics of pre-existing humoral imprint determine efficacy of S. aureus vaccines and support alternative vaccine approaches
JR Caldera, CM Tsai, D Trieu, C Gonzalez… - Cell Reports …, 2024 - cell.com
The failure of the Staphylococcus aureus (SA) IsdB vaccine trial can be explained by the
recall of non-protective immune imprints from prior SA exposure. Here, we investigate …
recall of non-protective immune imprints from prior SA exposure. Here, we investigate …
Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse models
Antibodies bind target molecules with exquisite specificity. The removal of these targets is
mediated by the effector functions of antibodies. We reported earlier that the monoclonal …
mediated by the effector functions of antibodies. We reported earlier that the monoclonal …
[HTML][HTML] Retrospective Study on Staphylococcus aureus Resistance Profile and Antibiotic Use in a Pediatric Population
D Buonsenso, M Giaimo, D Pata, A Rizzi, B Fiori… - Antibiotics, 2023 - mdpi.com
The growing phenomenon of antibiotic resistance and the presence of limited data
concerning the pediatric area prompted us to focus on Staphylococcus aureus infection in …
concerning the pediatric area prompted us to focus on Staphylococcus aureus infection in …
PBITV3: A robust and comprehensive tool for screening pathogenic proteomes for drug targets and prioritizing vaccine candidates
S Chakraborty, M Askari, RS Barai… - Protein …, 2024 - Wiley Online Library
Rise of life‐threatening superbugs, pandemics and epidemics warrants the need for cost‐
effective and novel pharmacological interventions. Availability of publicly available …
effective and novel pharmacological interventions. Availability of publicly available …