The Nrf2 transcription factor governs the expression of hundreds genes involved in cell
defense against oxidative stress, the hallmark of numerous diseases such as …

Abstract The KEAP1-NRF2-ARE signaling pathway plays a central role in mediating the
adaptive cellular stress response to oxidative and electrophilic chemicals. This canonical …

Exposure to antioxidants and xenobiotics triggers the expression of a myriad of genes
encoding antioxidant proteins, detoxifying enzymes, and xenobiotic transporters to offer …

Abstract Nuclear Factor Erythroid 2-related factor 2 (Nrf2) is a transcription factor that
regulates the expression of genes involved in the metabolism, immune response, cellular …

Inflammatory bowel diseases (IBD), encompassing Crohn's disease (CD) and ulcerative
colitis (UC), are intimately associated with inflammation and overproduction of reactive …

BACKGROUND: Glutathione (GSH) is present in all mammalian tissues as the most
abundant non-protein thiol that defends against oxidative stress. GSH is also a key …

The transcription factor nuclear factor erythroid-derived 2-like 2 (NRF2) participates in the
activation of the antioxidant cytoprotective pathway and other important physiological …

An elaborate network of highly inducible proteins protects aerobic cells against the
cumulative damaging effects of reactive oxygen intermediates and toxic electrophiles, which …

Multiple roles have been indicated for reactive oxygen species (ROS) in the immune system
in recent years. ROS have been extensively studied due to their ability to damage DNA and …

Neurodegenerative disorders affect more than fifty million Americans each year and
represent serious health threats as the population ages. Neuroinflammation and oxidative …