Microfluidic nanoparticles for drug delivery

Y Liu, G Yang, Y Hui, S Ranaweera, CX Zhao - Small, 2022 - Wiley Online Library
Nanoparticles (NPs) have attracted tremendous interest in drug delivery in the past decades.
Microfluidics offers a promising strategy for making NPs for drug delivery due to its capability …

Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Strategies, design, and chemistry in siRNA delivery systems

Y Dong, DJ Siegwart, DG Anderson - Advanced drug delivery reviews, 2019 - Elsevier
Emerging therapeutics that utilize RNA interference (RNAi) have the potential to treat broad
classes of diseases due to their ability to reversibly silence target genes. In August 2018, the …

CD44-targeted nanocarrier for cancer therapy

P Kesharwani, R Chadar, A Sheikh, WY Rizg… - Frontiers in …, 2022 - frontiersin.org
Cluster of differentiation 44 (CD44) is a cell surface glycoprotein overexpressed in varieties
of solid tumors including pancreatic, breast, ovary, brain, and lung cancers. It is a multi …

Nanocarriers for cancer-targeted drug delivery

P Kumari, B Ghosh, S Biswas - Journal of drug targeting, 2016 - Taylor & Francis
Nanoparticles as drug delivery system have received much attention in recent years,
especially for cancer treatment. In addition to improving the pharmacokinetics of the loaded …

Surface modification and endothelialization of biomaterials as potential scaffolds for vascular tissue engineering applications

X Ren, Y Feng, J Guo, H Wang, Q Li, J Yang… - Chemical Society …, 2015 - pubs.rsc.org
Surface modification and endothelialization of vascular biomaterials are common
approaches that are used to both resist the nonspecific adhesion of proteins and improve …

Biodegradable synthetic polymers: Preparation, functionalization and biomedical application

H Tian, Z Tang, X Zhuang, X Chen, X Jing - Progress in Polymer Science, 2012 - Elsevier
Biodegradable polymers have been widely used and have greatly promoted the
development of biomedical fields because of their biocompatibility and biodegradability. The …

Multifunctional polymeric micelles for delivery of drugs and siRNA

AM Jhaveri, VP Torchilin - Frontiers in pharmacology, 2014 - frontiersin.org
Polymeric micelles, self-assembling nano-constructs of amphiphilic copolymers with a core-
shell structure have been used as versatile carriers for delivery of drugs as well as nucleic …

Knocking down barriers: advances in siRNA delivery

KA Whitehead, R Langer, DG Anderson - Nature reviews Drug …, 2009 - nature.com
In the 10 years that have passed since the Nobel prize-winning discovery of RNA
interference (RNAi), billions of dollars have been invested in the therapeutic application of …

[HTML][HTML] Current challenges of cancer anti-angiogenic therapy and the promise of nanotherapeutics

AME Abdalla, L Xiao, MW Ullah, M Yu, C Ouyang… - Theranostics, 2018 - ncbi.nlm.nih.gov
With growing interest in cancer therapeutics, anti-angiogenic therapy has received
considerable attention and is widely administered in several types of human cancers …