Reactive oxygen species (ROS) modulate sphingolipid metabolism, including enzymes that
generate ceramide and sphingosine-1-phosphate (S1P), and a ROS-antioxidant rheostat …

Src family kinases (SFKs) is a non-receptor protein tyrosine kinases family. They are crucial
in signal transduction and regulation of various cell biological processes, such as …

Acetaminophen (APAP) is the leading cause of drug-induced acute liver failure.
Sphingosine-1-phosphate (S1P), whose formation is catalyzed by sphingosine kinase …

Sphingolipid molecules have recently attracted attention as signaling molecules in allergic
inflammation diseases. Sphingosine-1-phosphate (S1P) is synthesized by two isoforms of …

Gastric cancer is one of the most lethal cancers worldwide. FYN, a gene that is differentially
expressed in gastric cancer, is considered a critical metastasis regulator in several solid …

Background Activation of renal fibroblasts into myofibroblasts plays an important role in
promoting renal interstitial fibrosis (RIF). Ginkgo biloba extract (EGb) can alleviate RIF …

Chronic kidney disease (CKD) is a multifactorial condition with diverse etiologies, such as
diabetes mellitus, hypertension, and genetic disorders, often culminating in end-stage renal …

The Covid-19 pandemic driven by the SARS-CoV-2 virus continues to exert extensive
humanitarian and economic stress across the world. Although antivirals active against mild …

Fibrosis is characterized by the excessive accumulation of extracellular matrix components,
leading to loss of tissue function in affected organs. Although the majority of fibrotic diseases …

Transforming growth factor-β1 (TGF-β1) plays a premier role in fibrosis. To understand the
molecular events underpinning TGF-β1-induced fibrogenesis, we examined the proteomic …