Chimeric antigen receptor T (CAR-T) cell therapy represents a major breakthrough in cancer
treatment, and it has achieved unprecedented success in hematological malignancies …

Myelofibrosis (MF) is a myeloproliferative disorder that exhibits considerable biological and
clinical heterogeneity. At the two ends of the disease spectrum are the myelodepletive or …

Persistent symptoms following SARS-CoV-2 infection are increasingly reported, although
the drivers of post-acute sequelae (PASC) of COVID-19 are unclear. Here we assessed 214 …

Several molecular patterns have been identified that recognize pattern recognition
receptors. Pathogen-associated molecular patterns (PAMPs) and damage-associated …

Diabetes Mellitus (DM) is a complex metabolic disorder associated with multiple
microvascular complications leading to nephropathy, retinopathy, and neuropathy. Mounting …

The erythroblastic island (EBI), composed of a central macrophage surrounded by maturing
erythroblasts, is the erythroid precursor niche. Despite numerous studies, its precise …

Erythroblasts possess unique characteristics as they undergo differentiation from
hematopoietic stem cells. During terminal erythropoiesis, these cells incorporate large …

Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal hematological
diseases and a high risk for transformation to acute myeloid leukemia (AML). The …

Anemia commonly occurs in systemic lupus erythematosus, a disease characterized by
innate immune activation by nucleic acids. Overactivation of cytoplasmic sensors by self …

Introduction: Erythropoietin (EPO), produced in the kidney in a hypoxia responsive manner,
is required for red blood cell production. In non-erythroid tissue, EPO increases endothelial …