Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of
essentially all cell types. MHC ligands that trigger a T cell immune response are referred to …

Antigen presentation lies at the heart of immune recognition of infected or malignant cells.
For this reason, important efforts have been made to predict which peptides are more likely …

T cells are involved in control of SARS-CoV-2 infection. To establish the patterns of
immunodominance of different SARS-CoV-2 antigens and precisely measure virus-specific …

Major histocompatibility complex (MHC) molecules are expressed on the cell surface, where
they present peptides to T cells, which gives them a key role in the development of T-cell …

Major histocompatibility complex II (MHC II) molecules play a vital role in the onset and
control of cellular immunity. In a highly selective process, MHC II presents peptides derived …

Predictions of epitopes presented by class II human leukocyte antigen molecules (HLA-II)
have limited accuracy, restricting vaccine and therapy design. Here we combined unbiased …

Increasing evidence indicates CD4+ T cells can recognize cancer-specific antigens and
control tumor growth. However, it remains difficult to predict the antigens that will be …

CD4+ T cells orchestrate the adaptive immune response against pathogens and cancer by
recognizing epitopes presented on class II major histocompatibility complex (MHC-II) …

Accurate prediction of antigen presentation by human leukocyte antigen (HLA) class II
molecules is crucial for rational development of immunotherapies and vaccines targeting …

Prioritization of immunogenic neoantigens is key to enhancing cancer immunotherapy
through the development of personalized vaccines, adoptive T cell therapy, and the …