Reconstruction of bone defects, especially the critical-sized defects, with mechanical
integrity to the skeleton is important for a patient's rehabilitation, however, it still remains …

Epimedium (Berberidaceae), is a genus of about 52 species in the family Berberidaceae,
which also known as Rowdy Lamb Herb, Xianlinpi, Barrenwort, Bishop's Hat, Fairy Wings …

The pace of bone formation slows down with aging, which leads to the development of
osteoporosis. In addition to senescent bone marrow mesenchymal stem cells (S-BMSCs) …

Fragility fractures can cause significant morbidity and mortality in patients with osteoporosis
and inflict a considerable medical and socioeconomic burden. Moreover, treatment of an …

Stem cell therapy has revolutionized modern clinical therapy with the potential of stem cells
to differentiate into many different cell types which may help to replace different cell lines of …

Bone development is dynamically regulated by homeostasis, in which a balance between
adipocytes and osteoblasts is maintained. Disruption of this differentiation balance leads to …

Osteoporosis, or bone loss, is a progressive, systemic skeletal disease that affects millions of
people worldwide. Osteoporosis is generally age related, and it is underdiagnosed because …

Skeletal tissue damage caused by trauma, injury, or disease can often result in considerable
morbidity and the need for new, more reliable strategies for skeletal regeneration. So, to …

Mesenchymal stem cells derived from bone marrow (BM-MSCs) can differentiate into
adipocytes and osteoblasts. Various external stimuli, including environmental contaminants …

Osteogenesis of mesenchymal stem cells (MSCs) has played a necessary role in the repair
of bone. According to some reports, microRNAs participate in different physiological activity …