Clinical and preclinical outcomes of combining targeted therapy with radiotherapy

M Elbanna, NN Chowdhury, R Rhome… - Frontiers in …, 2021 - frontiersin.org
In the era of precision medicine, radiation medicine is currently focused on the precise
delivery of highly conformal radiation treatments. However, the tremendous developments in …

Review of current treatment intensification strategies for prostate cancer patients

S Wasim, J Park, S Nam, J Kim - Cancers, 2023 - mdpi.com
Simple Summary Prostate cancer (PCa) affects millions of men worldwide, and the mortality
rate for locally advanced or metastasized cancer cases remains high. Despite the …

Harnessing data science to advance radiation oncology

IR Vogelius, J Petersen, SM Bentzen - Molecular oncology, 2020 - Wiley Online Library
Radiation oncology, a major treatment modality in the care of patients with malignant
disease, is a technology‐and computer‐intensive medical specialty. As such, it should lend …

Personalization in modern radiation oncology: methods, results and pitfalls. Personalized interventions and breast cancer

C Aristei, E Perrucci, E Alì, F Marazzi, V Masiello… - Frontiers in …, 2021 - frontiersin.org
Breast cancer, the most frequent malignancy in women worldwide, is a heterogeneous
group of diseases, characterized by distinct molecular aberrations. In precision medicine …

dbCRAF: a curated knowledgebase for regulation of radiation response in human cancer

J Liu, J Li, F Jin, Q Li, G Zhao, L Wu, X Li, J Xia… - NAR …, 2024 - academic.oup.com
Radiation therapy (RT) is one of the primary treatment modalities of cancer, with 40–60% of
cancer patients benefiting from RT during their treatment course. The intrinsic …

Pan-cancer analysis of radiotherapy benefits and immune infiltration in multiple human cancers

P Wen, Y Gao, B Chen, X Qi, G Hu, A Xu, J Xia, L Wu… - Cancers, 2020 - mdpi.com
Response to radiotherapy (RT) in cancers varies widely among patients. Therefore, it is very
important to predict who will benefit from RT before clinical treatment. Consideration of the …

Developing more sensitive genomic approaches to detect radioresponse in precision radiation oncology: From tissue DNA analysis to circulating tumor DNA

K He, S Zhang, LL Shao, JC Yin, X Wu, YW Shao… - Cancer Letters, 2020 - Elsevier
Despite the common application and considerable efforts to achieve precision radiotherapy
(RT) in several types of cancer, RT has not yet entered the era of precision medicine; the …

Local Disease-Free Survival Rate (LSR) Application to Personalize Radiation Therapy Treatments in Breast Cancer Models

G Savoca, M Calvaruso, L Minafra, V Bravatà… - Journal of personalized …, 2020 - mdpi.com
Cancer heterogeneity represents the main issue for defining an effective treatment in clinical
practice, and the scientific community is progressively moving towards the development of …

The State of Preclinical Modeling for Early Phase Cancer Trials Using Molecularly Targeted Agents with Radiation

JA Hong, B Vikram, J Buchsbaum… - Radiation …, 2022 - meridian.allenpress.com
Preclinical studies inform and guide the development of novel treatment combination
strategies that bridge the laboratory with the clinic. We aimed to evaluate approaches cancer …

Predicting outcome using genomic-based liquid biomarkers

B Marples, GD Wilson - International journal of radiation oncology …, 2020 - redjournal.org
Predicting Outcome using Genomic-Based Liquid Biomarkers - International Journal of Radiation
Oncology, Biology, Physics Skip to Main Content Advertisement International Journal of …