Immune checkpoint inhibitor therapy has revolutionized the treatment of advanced
malignancies in recent years. Numerous reports have detailed the myriad of possible …

As the clinical applications of immune checkpoint inhibitors (ICIs) expand, our knowledge of
the potential adverse effects of these drugs continues to broaden. Emerging evidence …

Atherosclerosis is a chronic progressive inflammatory disease of the large and medium-
sized artery walls. The molecular mechanisms regulating the onset and progression of …

This review based on the ESC William Harvey Lecture in Basic Science 2022 highlights
recent experimental and translational progress on the therapeutic targeting of the …

Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipid-
rich plaques within arterial walls. T cells play a pivotal role in the pathogenesis of …

Atherosclerotic cardiovascular disease is a major cause of disability and death worldwide.
Most therapeutic approaches target traditional risk factors but ignore the fundamental role of …

The leading cause of heart disease in developed countries is coronary atherosclerosis,
which is not simply a result of ageing but a chronic inflammatory process that can lead to …

Chronic inflammatory microenvironment is the predominant milieu that promotes the
progression of atherosclerosis (AS). However, targeted regulation of the chronic …

Atherosclerosis and its clinical manifestations, coronary and cerebral artery diseases, are
the most common cause of death worldwide. The main pathophysiological mechanism for …

The immune system is integral to cardiovascular health and disease. Targeting inflammation
ameliorates adverse cardiovascular outcomes. Atherosclerosis, a major underlying cause of …