Hydrogen sulfide (H2S) has become recognized as an important signalling molecule
throughout the body, contributing to many physiological and pathological processes. In …

Twenty years ago, Rho-kinase was identified as an important downstream effector of the
small GTP-binding protein, RhoA. Thereafter, a series of studies demonstrated the important …

Cellular exposure to ionizing radiation leads to oxidizing events that alter atomic structure
through direct interactions of radiation with target macromolecules or via products of water …

Significance: Protein S-nitrosylation, the oxidative modification of cysteine by nitric oxide
(NO) to form protein S-nitrosothiols (SNOs), mediates redox-based signaling that conveys, in …

Nitric oxide synthases are the major sources of nitric oxide, a critical signaling molecule
involved in a wide range of cellular and physiological processes. These enzymes comprise …

The thioredoxin (Trx) system is one of the central antioxidant systems in mammalian cells,
maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine …

Significance: All cells must maintain a balance between oxidants and reductants, while
allowing for fluctuations in redox states triggered by signaling, altered metabolic flow, or …

Autophagy is a ubiquitous homeostatic mechanism for the degradation or turnover of cellular
components. Degradation of mitochondria via autophagy (mitophagy) is involved in a …

Nitric oxide participates in cellular signal transduction largely through S-nitrosylation of
allosteric and active-site cysteine thiols within proteins, forming S-nitroso-proteins (SNO …

Abstract Significance: The thioredoxin (Trx) system, comprising nicotinamide adenine
dinucleotide phosphate, Trx reductase (TrxR), and Trx, is critical for maintaining cellular …