The physical distance between presynaptic Ca2+ channels and the Ca2+ sensors that
trigger exocytosis of neurotransmitter-containing vesicles is a key determinant of the …

Acoustic communication requires gathering, transforming, and interpreting diverse sound
cues. To achieve this, all the spatial and temporal features of complex sound stimuli must be …

Glutamatergic synapses display variable strength and diverse short-term plasticity (STP),
even for a given type of connection. Using nonnegative tensor factorization and …

Fast synaptic transmission is important for rapid information processing. To explore the
maximal rate of neuronal signaling and to analyze the presynaptic mechanisms, we focused …

Mammalian cochlear spiral ganglion neurons (SGNs) encode sound with microsecond
precision. Spike triggering relies upon input from a single ribbon-type active zone of a …

Complexins (Cplxs) are small synaptic proteins that cooperate with SNARE-complexes in
the control of synaptic vesicle (SV) fusion. Studies involving genetic mutation, knock-down …

Rab-interacting molecule (RIM)-binding protein 2 (BP2) is a multidomain protein of the
presynaptic active zone (AZ). By binding to RIM, bassoon (Bsn), and voltage-gated Ca 2+ …

The auxiliary subunit α2δ3 modulates the expression and function of voltage-gated calcium
channels. Here we show that α2δ3 mRNA is expressed in spiral ganglion neurons and …

Synaptic transmission via chemical synapses is dynamic, ie, the strength of postsynaptic
responses may change considerably in response to repeated synaptic activation. Synaptic …

The spatial arrangement of Ca2+ channels and vesicles remains unknown for most CNS
synapses, despite of the crucial importance of this geometrical parameter for the Ca2+ …