Targeting integrin pathways: mechanisms and advances in therapy

X Pang, X He, Z Qiu, H Zhang, R Xie, Z Liu… - … and Targeted Therapy, 2023 - nature.com
Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Semaphorins and their signaling mechanisms

LT Alto, JR Terman - Semaphorin Signaling: Methods and Protocols, 2017 - Springer
Semaphorins are extracellular signaling proteins that are essential for the development and
maintenance of many organs and tissues. The more than 20-member semaphorin protein …

The integrin–collagen connection–a glue for tissue repair?

C Zeltz, D Gullberg - Journal of cell science, 2016 - journals.biologists.com
ABSTRACT The α1β1, α2β1, α10β1 and α11β1 integrins constitute a subset of the integrin
family with affinity for GFOGER-like sequences in collagens. Integrins α1β1 and α2β1 were …

Semaphorins and plexins as therapeutic targets

T Worzfeld, S Offermanns - Nature reviews Drug discovery, 2014 - nature.com
Semaphorins are membrane-bound or diffusible factors that regulate key cellular functions
and are involved in cell–cell communication. Most of the effects of semaphorins are …

Fibrocytes: emerging effector cells in chronic inflammation

RA Reilkoff, R Bucala, EL Herzog - Nature Reviews Immunology, 2011 - nature.com
Fibrocytes are mesenchymal cells that arise from monocyte precursors. They are present in
injured organs and have both the inflammatory features of macrophages and the tissue …

Effector and regulatory mechanisms in allergic contact dermatitis

M Vocanson, A Hennino, A Rozieres, G Poyet… - Allergy, 2009 - Wiley Online Library
Allergic contact dermatitis (ACD), one of the commonest occupational diseases, is a T‐cell‐
mediated skin inflammation caused by repeated skin exposure to contact allergens, ie …

Distinct epigenetic signatures delineate transcriptional programs during virus-specific CD8+ T cell differentiation

BE Russ, M Olshanksy, HS Smallwood, J Li, AE Denton… - Immunity, 2014 - cell.com
The molecular mechanisms that regulate the rapid transcriptional changes that occur during
cytotoxic T lymphocyte (CTL) proliferation and differentiation in response to infection are …

Immunological functions of the neuropilins and plexins as receptors for semaphorins

A Kumanogoh, H Kikutani - Nature reviews Immunology, 2013 - nature.com
Semaphorins were originally identified as axon-guidance molecules that function during
neuronal development. However, cumulative evidence indicates that semaphorins also …

Cooperation between integrins and growth factor receptors in signaling and endocytosis

J Ivaska, J Heino - Annual review of cell and developmental …, 2011 - annualreviews.org
All multicellular animals express receptors for growth factors (GFs) and extracellular matrix
(ECM) molecules. Integrin-type ECM receptors anchor cells to their surroundings and …

Semaphorins and their receptors in immune cell interactions

K Suzuki, A Kumanogoh, H Kikutani - Nature immunology, 2008 - nature.com
Semaphorins are newcomers to the growing panoply of immunoregulatory proteins.
Members of this family were originally identified as proteins that provide axonal guidance …