Targeting integrin pathways: mechanisms and advances in therapy
X Pang, X He, Z Qiu, H Zhang, R Xie, Z Liu… - … and Targeted Therapy, 2023 - nature.com
Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …
Semaphorins and their signaling mechanisms
LT Alto, JR Terman - Semaphorin Signaling: Methods and Protocols, 2017 - Springer
Semaphorins are extracellular signaling proteins that are essential for the development and
maintenance of many organs and tissues. The more than 20-member semaphorin protein …
maintenance of many organs and tissues. The more than 20-member semaphorin protein …
The integrin–collagen connection–a glue for tissue repair?
C Zeltz, D Gullberg - Journal of cell science, 2016 - journals.biologists.com
ABSTRACT The α1β1, α2β1, α10β1 and α11β1 integrins constitute a subset of the integrin
family with affinity for GFOGER-like sequences in collagens. Integrins α1β1 and α2β1 were …
family with affinity for GFOGER-like sequences in collagens. Integrins α1β1 and α2β1 were …
Semaphorins and plexins as therapeutic targets
T Worzfeld, S Offermanns - Nature reviews Drug discovery, 2014 - nature.com
Semaphorins are membrane-bound or diffusible factors that regulate key cellular functions
and are involved in cell–cell communication. Most of the effects of semaphorins are …
and are involved in cell–cell communication. Most of the effects of semaphorins are …
Fibrocytes: emerging effector cells in chronic inflammation
Fibrocytes are mesenchymal cells that arise from monocyte precursors. They are present in
injured organs and have both the inflammatory features of macrophages and the tissue …
injured organs and have both the inflammatory features of macrophages and the tissue …
Effector and regulatory mechanisms in allergic contact dermatitis
M Vocanson, A Hennino, A Rozieres, G Poyet… - Allergy, 2009 - Wiley Online Library
Allergic contact dermatitis (ACD), one of the commonest occupational diseases, is a T‐cell‐
mediated skin inflammation caused by repeated skin exposure to contact allergens, ie …
mediated skin inflammation caused by repeated skin exposure to contact allergens, ie …
Distinct epigenetic signatures delineate transcriptional programs during virus-specific CD8+ T cell differentiation
The molecular mechanisms that regulate the rapid transcriptional changes that occur during
cytotoxic T lymphocyte (CTL) proliferation and differentiation in response to infection are …
cytotoxic T lymphocyte (CTL) proliferation and differentiation in response to infection are …
Immunological functions of the neuropilins and plexins as receptors for semaphorins
A Kumanogoh, H Kikutani - Nature reviews Immunology, 2013 - nature.com
Semaphorins were originally identified as axon-guidance molecules that function during
neuronal development. However, cumulative evidence indicates that semaphorins also …
neuronal development. However, cumulative evidence indicates that semaphorins also …
Cooperation between integrins and growth factor receptors in signaling and endocytosis
J Ivaska, J Heino - Annual review of cell and developmental …, 2011 - annualreviews.org
All multicellular animals express receptors for growth factors (GFs) and extracellular matrix
(ECM) molecules. Integrin-type ECM receptors anchor cells to their surroundings and …
(ECM) molecules. Integrin-type ECM receptors anchor cells to their surroundings and …
Semaphorins and their receptors in immune cell interactions
K Suzuki, A Kumanogoh, H Kikutani - Nature immunology, 2008 - nature.com
Semaphorins are newcomers to the growing panoply of immunoregulatory proteins.
Members of this family were originally identified as proteins that provide axonal guidance …
Members of this family were originally identified as proteins that provide axonal guidance …