Adenoviral infections continue posing a major threat in severely immunocompromised
patients including particularly allogeneic stem cell transplant recipients. Although …

Mice xenotransplanted with human cells and/or expressing human gene products (also
known as “humanized mice”) recapitulate the human evolutionary specialization and …

Adenoviruses are a commonly utilized virus for gene therapy platforms worldwide. Since
adenovirus components are characterized as highly immunogenic, their immunogenicity …

With an increasing human population, medical research is pushed to progress into an era of
precision therapy. Humanized mice are at the very heart of this new forefront where it is …

Simple Summary Animal models are widely used to study various aspects of human
diseases and disorders. Likewise, they are indispensable for preclinical testing of medicals …

Humanized mice are increasingly appreciated as an incredibly powerful platform for
infectious disease research. The often very narrow species tropism of many viral infections …

Human adenovirus (HAdV) causes infections predominantly in early childhood and the
tissue tropism of specific HAdV species determines the clinical manifestation, including …

Eukaryotic cells recognize intracellular pathogens through pattern recognition receptors,
including sensors of aberrant nucleic acid structures. Sensors of double-stranded RNA …

Biomaterials are widely used to produce devices for regenerative medicine. After its
implantation, an interaction between the host immune system and the implanted biomaterial …

Filoviruses of the genus Ebolavirus include 6 species with marked differences in their ability
to cause disease in humans. From the highly virulent Ebola virus to the seemingly …