Epithelial cells are the most common cell type in all animals, forming the sheets and tubes
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …

Hepatocytes, like other epithelia, are situated at the interface between the organism's
exterior and the underlying internal milieu and organize the vectorial exchange of …

The par genes were discovered in genetic screens for regulators of cytoplasmic partitioning
in the early embryo of C. elegans, and encode six different proteins required for asymmetric …

Ten years ago, par-1 and par-3 were cloned as two of the six par genes essential for the
asymmetric division of the Caenorhabditis elegans zygote. PAR-1 is a protein kinase …

PAR-1 kinases are required for polarity in diverse cell types, such as epithelial cells, where
they localize laterally. PAR-1 activity is believed to be transduced by binding of 14-3-3 …

Multisite hyperphosphorylation of tau has been implicated in the pathogenesis of
neurodegenerative diseases including Alzheimer's disease (AD). However, the …

Two PDZ-domain-containing adapter-like proteins, PAR-3 and PAR-6, and a protein kinase,
atypical protein kinase C (PKC), cooperate together to establish cell polarity in a variety of …

Excessive activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome is
involved in many chronic inflammatory diseases, including cardiovascular and Alzheimer's …

▪ Abstract Translational control is a prevalent means of gene regulation during Drosophila
oogenesis and embryogenesis. Multiple maternal mRNAs are localized within the oocyte …

The anterior–posterior axis of Drosophila is established before fertilisation when the oocyte
becomes polarised to direct the localisation of bicoid and oskar mRNAs to opposite poles of …