Glycomimetics for the inhibition and modulation of lectins

S Leusmann, P Ménová, E Shanin, A Titz… - Chemical Society …, 2023 - pubs.rsc.org
Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …

Small carbohydrate derivatives as potent antibiofilm agents

K Singh, SS Kulkarni - Journal of Medicinal Chemistry, 2022 - ACS Publications
Biofilm formation by most pathogenic bacteria is considered as one of the key mechanisms
associated with virulence and antibiotic resistance. Biofilm-forming bacteria adhere to the …

Powerful avidity with a limited valency for virus-attachment blockers on DC-SIGN: combining chelation and statistical rebinding with structural plasticity of the receptor

V Porkolab, M Lepsik, S Ordanini, A St John… - ACS Central …, 2023 - ACS Publications
The C-type lectin receptor DC-SIGN has been highlighted as the coreceptor for the spike
protein of the SARS-CoV-2 virus. A multivalent glycomimetic ligand, Polyman26, has been …

Lectin-Targeted Prodrugs Activated by Pseudomonas aeruginosa for Self-Destructive Antibiotic Release

J Meiers, K Rox, A Titz - Journal of Medicinal Chemistry, 2022 - ACS Publications
Chronic Pseudomonas aeruginosa infections are characterized by biofilm formation, a major
virulence factor of P. aeruginosa and cause of extensive drug resistance. Fluoroquinolones …

Neutralizing the Impact of the Virulence Factor LecA from Pseudomonas aeruginosa on Human Cells with New Glycomimetic Inhibitors

E Zahorska, F Rosato, K Stober… - Angewandte Chemie …, 2023 - Wiley Online Library
Bacterial adhesion, biofilm formation and host cell invasion of the ESKAPE pathogen
Pseudomonas aeruginosa require the tetravalent lectins LecA and LecB, which are …

Discovery of N-β-l-Fucosyl Amides as High-Affinity Ligands for the Pseudomonas aeruginosa Lectin LecB

P Mała, E Siebs, J Meiers, K Rox, A Varrot… - Journal of Medicinal …, 2022 - ACS Publications
The Gram-negative pathogen Pseudomonas aeruginosa causes severe infections mainly in
immunocompromised or cystic fibrosis patients and is able to resist antimicrobial treatments …

Targeting extracellular lectins of Pseudomonas aeruginosa with glycomimetic liposomes

O Metelkina, B Huck, JS O'Connor, M Koch… - Journal of Materials …, 2022 - pubs.rsc.org
The antimicrobial resistance crisis requires novel approaches for the therapy of infections
especially with Gram-negative pathogens. Pseudomonas aeruginosa is defined as priority 1 …

Structural Considerations for Building Synthetic Glycoconjugates as Inhibitors for Pseudomonas aeruginosa Lectins

K Wojtczak, JP Byrne - ChemMedChem, 2022 - Wiley Online Library
Pseudomonas aeruginosa is a pathogenic bacterium, responsible for a large portion of
nosocomial infections globally and designated as critical priority by the World Health …

High-Affinity Lectin Ligands Enable the Detection of Pathogenic Pseudomonas aeruginosa Biofilms: Implications for Diagnostics and Therapy

E Zahorska, LM Denig, S Lienenklaus… - JACS Au, 2024 - ACS Publications
Pseudomonas aeruginosa is a critical priority pathogen and causes life-threatening acute
and biofilm-associated chronic infections. The choice of suitable treatment for complicated …

Targeting the Central Pocket of the Pseudomonas aeruginosa Lectin LecA

E Siebs, E Shanina, S Kuhaudomlarp… - …, 2022 - Wiley Online Library
Pseudomonas aeruginosa is an opportunistic ESKAPE pathogen that produces two lectins,
LecA and LecB, as part of its large arsenal of virulence factors. Both carbohydrate‐binding …