Nonalcoholic fatty liver disease (NAFLD), a series of liver metabolic disorders manifested by
lipid accumulation within hepatocytes, has become the primary cause of chronic liver …

The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

Farnesoid X receptor (FXR) is a promising target for nonalcoholic steatohepatitis (NASH)
and fibrosis. Although various FXR agonists have shown anti-fibrotic effects in diverse …

ABSTRACT Introduction: Farnesoid X receptor (FXR), a nuclear receptor mainly expressed
in enterohepatic tissues, is a master for bile acid, lipid and glucose homeostasis …

Obeticholic acid (OCA), the first FXR-targeting drug, has been claimed effective in the
therapy of liver fibrosis. However, recent clinical trials indicated that OCA might not be …

Bile acids, once considered mere dietary surfactants, now emerge as critical modulators of
macronutrient (lipid, carbohydrate, protein) metabolism and the systemic pro …

The nuclear receptor farnesoid-X-receptor (FXR) plays an essential role in bile acid,
glucose, and lipid homeostasis. In the last two decades, several diseases, such as obesity …

The prevalence of nonalcoholic steatohepatitis (NASH) is increasing rapidly worldwide, and
NASH has become a serious problem for human health. Recently, the selective activation of …

Liver diseases and related complications have become one of the leading causes of
morbidity and mortality worldwide, yet effective medicine or approved treatment approach is …

Farnesoid X receptor (FXR) was considered as a promising drug target in the treatment of
cholestasis, drug-induced liver injury, and non-alcoholic steatohepatitis (NASH). However …