Calcium signaling underlies much of physiology. Almost all the Ca2+ in the cytoplasm is
bound to buffers, with typically only∼ 1% being freely ionized at resting levels in most cells …

Calcium influx through voltage-gated Ca (CaV) channels is the first step in synaptic
transmission. This review concerns CaV channels at ribbon synapses in primary sense …

The hexa-EF-hand Ca2+-binding protein calretinin (CR) is predominantly expressed in
specific neurons of the central and peripheral nervous system. However, CR expression is …

Background There is increasing evidence that Parkinson's disease (PD) might start in the
gut, thus involving and compromising also the enteric nervous system (ENS). At the clinical …

For precisely regulating intracellular Ca2+ signals in a time-and space-dependent manner,
cells make use of various components of the “Ca2+ signaling toolkit,” including Ca2+ entry …

EF-hand Ca2+-binding proteins are thought to shape the spatiotemporal properties of
cellular Ca2+ signaling and are prominently expressed in sensory hair cells in the ear. Here …

The coupling distance between presynaptic Ca 2+ influx and the sensor for vesicular
transmitter release determines speed and reliability of synaptic transmission [1, 2] …

Epilepsy is a common neurological disorder characterized by hyperexcitability in the brain.
Its pathogenesis is classically associated with an imbalance of excitatory and inhibitory …

The amyloid-β precursor protein (APP) is a transmembrane protein that is widely expressed
within the central nervous system (CNS). While the pathogenic dysfunction of this protein …

Malignant mesothelioma (MM) are highly aggressive asbestos‐related neoplasms, which
show strong chemotherapy resistance, and there is no effective cure for MM so far. Calretinin …