The molecular basis of working mechanism of natural polyphenolic antioxidants

M Leopoldini, N Russo, M Toscano - Food chemistry, 2011 - Elsevier
In this review, we present a summary of the research work performed so far using high
accuracy quantum chemical methods on polyphenolic antioxidant compounds. We have …

Structure-antioxidant activity relationships of flavonoids and phenolic acids

CA Rice-Evans, NJ Miller, G Paganga - Free radical biology and medicine, 1996 - Elsevier
The recent explosion of interest in the bioactivity of the the flavonoids of higher plants is due,
at least in part, to the potential health benefits of these polyphenolic components of major …

The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer

E Middleton, C Kandaswami, TC Theoharides - Pharmacological reviews, 2000 - ASPET
Flavonoids are nearly ubiquitous in plants and are recognized as the pigments responsible
for the colors of leaves, especially in autumn. They are rich in seeds, citrus fruits, olive oil …

Fisetin: a dietary antioxidant for health promotion

N Khan, DN Syed, N Ahmad… - Antioxidants & redox …, 2013 - liebertpub.com
Significance: Diet-derived antioxidants are now being increasingly investigated for their
health-promoting effects, including their role in the chemoprevention of cancer. In general …

Review of the biology of quercetin and related bioflavonoids

JV Formica, W Regelson - Food and chemical toxicology, 1995 - Elsevier
The French paradox is a dietary anomaly which has focused attention on the Mediterranean
diet. Epidemiological studies revealed that this diet, replete in flavonoid-rich foods (Allium …

Psidium guajava: A review of its traditional uses, phytochemistry and pharmacology

RMP Gutiérrez, S Mitchell, RV Solis - Journal of ethnopharmacology, 2008 - Elsevier
Psidium guajava, is an important food crop and medicinal plant in tropical and subtropical
countries is widely used like food and in folk medicine around of the world. This aims a …

Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review

AR Ravula, SB Teegala, S Kalakotla… - European journal of …, 2021 - Elsevier
Neurodegenerative disorders pose a significant health burden and imprint a debilitative
impact on the quality of life. Importantly, aging is intricately intertwined with the progression …

Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition.

DR Ferry, A Smith, J Malkhandi, DW Fyfe… - Clinical cancer research …, 1996 - AACR
We have performed a Phase I clinical trial with the naturally occurring flavonoid quercetin (3,
3', 4', 5, 7-pentahydroxyflavone). Quercetin has antiproliferative activity in vitro and is known …

Flavonols and cardiovascular disease

F Perez-Vizcaino, J Duarte - Molecular aspects of medicine, 2010 - Elsevier
Flavonols, and specially quercetin, are widely distributed in plants and are present in
considerable amounts in fruits and vegetables. In addition to their anti-oxidant effect …

[HTML][HTML] Quercetin Reduces Blood Pressure in Hypertensive Subjects1

RL Edwards, T Lyon, SE Litwin, A Rabovsky… - The Journal of …, 2007 - Elsevier
Epidemiological studies report that quercetin, an antioxidant flavonol found in apples,
berries, and onions, is associated with reduced risk of coronary heart disease and stroke …