The individualization of immunosuppression is an approach for preventing rejection in the
early phase after transplantation and for avoiding the long-term side effects of over …

Activation of lymphocytes is a complex, yet finely regulated cascade of events that results in
the expression of cytokine receptors, production and secretion of cytokines and expression …

Gut intraepithelial lymphocytes (IELs) are thought to calibrate glucagon-like peptide 1 (GLP-
1) bioavailability, thereby regulating systemic glucose and lipid metabolism. Here, we show …

The release of cytokines by T cells defines a significant part of their functional activity in vivo,
and their ability to produce multiple cytokines has been associated with beneficial immune …

Antiretroviral therapy (ART) inhibits HIV-1 replication, but the virus persists in latently
infected resting memory CD4+ T cells susceptible to viral reactivation. The virus-encoded …

Natural killer (NK) cells are cytotoxic lymphocytes capable of rapid cytotoxicity, cytokine
secretion, and clonal expansion. To sustain such energetically demanding processes, NK …

Despite studies implicating adipose tissue T cells (ATT) in the initiation and persistence of
adipose tissue inflammation, fundamental gaps in knowledge regarding ATT function …

CD16A is a potent cytotoxicity receptor on human natural killer (NK) cells, which can be
exploited by therapeutic bispecific antibodies. So far, the effects of CD16A-mediated …

BACKGROUND:: The therapeutic value of secretolytic agents in COPD and asthma is still
disputed. For this reason, in a preclinical study we aimed to test the potential anti …

Innate cytokines are critical drivers of priming and differentiation of naive CD4 T cells, but
their functions in memory T cell response are largely undefined. Here we show that IL-1 acts …