Synovial sarcoma: defining features and diagnostic evolution

K Thway, C Fisher - Annals of diagnostic pathology, 2014 - Elsevier
Synovial sarcoma (SS) is a malignant mesenchymal neoplasm with variable epithelial
differentiation, with a propensity to occur in young adults and which can arise at almost any …

SWI/SNF chromatin remodeling complexes and cancer

JA Biegel, TM Busse… - American Journal of …, 2014 - Wiley Online Library
The identification of mutations and deletions in the SMARCB1 locus in chromosome band
22q11. 2 in pediatric rhabdoid tumors provided the first evidence for the involvement of the …

Impact of SYT-SSX Fusion Type on the Clinical Behavior of Synovial Sarcoma: A Multi-Institutional Retrospective Study of 243 Patients

M Ladanyi, CR Antonescu, DH Leung, JM Woodruff… - Cancer research, 2002 - AACR
Synovial sarcomas are aggressive spindle cell sarcomas containing in some cases areas of
epithelial differentiation. They consistently show a specific t (X; 18; p11; q11), which usually …

Histologic Grade, But Not SYT-SSX Fusion Type, Is an Important Prognostic Factor in Patients With Synovial Sarcoma: A Multicenter, Retrospective Analysis

L Guillou, J Benhattar, F Bonichon… - Journal of Clinical …, 2004 - ascopubs.org
Purpose To assess the prognostic value of SYT-SSX fusion type, in comparison with other
factors, in a population of 165 patients with synovial sarcoma (SS). Patients and Methods …

[HTML][HTML] A conditional mouse model of synovial sarcoma: insights into a myogenic origin

M Haldar, JD Hancock, CM Coffin, SL Lessnick… - Cancer cell, 2007 - cell.com
Synovial sarcoma is an aggressive soft-tissue malignancy marked by a unique t (X; 18)
translocation leading to expression of a chimeric SYT-SSX fusion protein. We report here a …

Synovial sarcoma: recent discoveries as a roadmap to new avenues for therapy

TO Nielsen, NM Poulin, M Ladanyi - Cancer discovery, 2015 - AACR
Oncogenesis in synovial sarcoma is driven by the chromosomal translocation t (X, 18; p11,
q11), which generates an in-frame fusion of the SWI/SNF subunit SS18 to the C-terminal …

Monophasic fibrous and poorly differentiated synovial sarcoma: immunohistochemical reassessment of 60 t (X; 18)(SYT-SSX)-positive cases

M Pelmus, L Guillou, I Hostein… - The American journal …, 2002 - journals.lww.com
Diagnosing monophasic fibrous and poorly differentiated synovial sarcoma (SS) on
morphology alone is often a source of problems for pathologists. SS bear the t (X; 18)(p11. 2 …

Chromosome instability accounts for reverse metastatic outcomes of pediatric and adult synovial sarcomas

P Lagarde, J Przybyl, C Brulard, G Pérot… - Journal of clinical …, 2013 - ascopubs.org
Purpose Synovial sarcoma (SS) occurs in both children and adults, although metastatic
events are much more common in adults. Whereas the importance of the t (X; 18) …

Synovial sarcoma: retrospective analysis of 250 patients treated at a single institution

E Palmerini, EL Staals, M Alberghini, L Zanella… - Cancer, 2009 - Wiley Online Library
BACKGROUND: The optimal treatment for synovial sarcoma remains controversial.
Treatment, outcome, and prognostic factors in patients treated in a single institution were …

[HTML][HTML] Primary pulmonary and mediastinal synovial sarcoma: a clinicopathologic study of 60 cases and comparison with five prior series

PH Hartel, JC Fanburg-Smith, AA Frazier, JR Galvin… - Modern Pathology, 2007 - Elsevier
Primary pulmonary and mediastinal synovial sarcoma is rare and poses a diagnostic
challenge particularly when unusual histological features are present. We present 60 cases …