Deciding what to do and when to move is vital to our survival. Clinical and fundamental
studies have identified basal ganglia circuits as critical for this process. The main input …

Autism spectrum disorders (ASD) are characterized by two seemingly unrelated symptom
domains—deficits in social interactions and restrictive, repetitive patterns of behavioral …

The mammalian brain is composed of diverse, specialized cell populations. To
systematically ascertain and learn from these cellular specializations, we used Drop-seq to …

Integrative brain functions depend on widely distributed, rhythmically coordinated
computations. Through its long-ranging connections with cortex and most senses, the …

The dynamical properties of cortico-basal ganglia (CBG) circuits are dramatically altered
following the loss of dopamine in Parkinson's disease (PD). The neural circuit dysfunctions …

The basal ganglia (BG) inhibit movements through two independent circuits: the striatal
neuron-indirect and the subthalamic nucleus-hyperdirect pathways. These pathways exert …

The basal ganglia regulate a wide range of behaviors, including motor control and cognitive
functions, and are profoundly affected in Parkinson's disease (PD). However, the functional …

The external globus pallidus (GP e) of the basal ganglia is in a unique and powerful position
to influence processing of motor information by virtue of its widespread projections to all …

An imbalance in goal-directed and habitual behavioral control is a hallmark of decision-
making–related disorders, including addiction. Although external globus pallidus (GPe) is …

The external globus pallidus (GPe) coordinates action-selection through GABAergic
projections throughout the basal ganglia. GPe arkypallidal (arky) neurons project exclusively …