Impacts of cigarette smoking on immune responsiveness: Up and down or upside down?

F Qiu, CL Liang, H Liu, YQ Zeng, S Hou, S Huang… - …, 2016 - pmc.ncbi.nlm.nih.gov
Cigarette smoking is associated with numerous diseases and poses a serious challenge to
the current healthcare system worldwide. Smoking impacts both innate and adaptive …

The role of TLRs in neutrophil activation

LR Prince, MK Whyte, I Sabroe, LC Parker - Current opinion in …, 2011 - Elsevier
Neutrophils are key innate immune effector cells that are rapidly recruited to sites of infection
and inflammation to provide early defence against invading microorganisms. This function is …

Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic airway inflammation in mice

SD Pouwels, GJ Zijlstra… - … of Physiology-Lung …, 2016 - journals.physiology.org
Recent data indicate a role for airway epithelial necroptosis, a regulated form of necrosis,
and the associated release of damage-associated molecular patterns (DAMPs) in the …

Airway epithelium dysfunction in cystic fibrosis and COPD

V De Rose, K Molloy, S Gohy, C Pilette… - Mediators of …, 2018 - Wiley Online Library
Cystic fibrosis is a genetic disease caused by mutations in the CFTR gene, whereas chronic
obstructive pulmonary disease (COPD) is mainly caused by environmental factors (mostly …

Implications of the immune landscape in COPD and lung cancer: smoking versus other causes

E Taucher, I Mykoliuk, J Lindenmann… - Frontiers in …, 2022 - frontiersin.org
Cigarette smoking is reported in about one third of adults worldwide. A strong relationship
between cigarette smoke exposure and chronic obstructive pulmonary disease (COPD) as …

[HTML][HTML] DAMPs activating innate and adaptive immune responses in COPD

SD Pouwels, IH Heijink, NH Ten Hacken… - Mucosal …, 2014 - Elsevier
Chronic obstructive pulmonary disease (COPD), a progressive lung disease characterized
by sustained neutrophilic airway inflammation, is caused by chronic exposure to noxious …

The role of HMGB1/RAGE/TLR4 signaling pathways in cigarette smoke‐induced inflammation in chronic obstructive pulmonary disease

L Lin, J Li, Q Song, W Cheng… - … inflammation and disease, 2022 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease
with irreversible and continuous progression. It has become the fifth most burdensome …

Lung antimicrobial proteins and peptides: From host defense to therapeutic strategies

YP Di, JM Kuhn, ML Mangoni - Physiological Reviews, 2024 - journals.physiology.org
Representing severe morbidity and mortality globally, respiratory infections associated with
chronic respiratory diseases, including complicated pneumonia, asthma, interstitial lung …

Toll like receptors in diseases of the lung

MA Kovach, TJ Standiford - International immunopharmacology, 2011 - Elsevier
The lung is in continuous contact with a diverse array of infectious agents, foreign antigens,
and host-derived danger signals. To sample this expansive internal and external milieu …

A synbiotic mixture of Bifidobacterium breve M16-V, oligosaccharides and pectin, enhances Short Chain Fatty Acid production and improves lung health in a …

GFG Bezemer, MAP Diks, E Mortaz, I van Ark… - Frontiers in …, 2024 - frontiersin.org
Introduction Pulmonary neutrophilia is a hallmark of numerous airway diseases including
Chronic Obstructive Pulmonary Disease (COPD), Neutrophilic asthma, Acute Lung Injury …