Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis

PA Muraro, R Martin, GL Mancardi, R Nicholas… - Nature Reviews …, 2017 - nature.com
Autologous haematopoietic stem cell transplantation (AHSCT) is a multistep procedure that
enables destruction of the immune system and its reconstitution from haematopoietic stem …

Autologous hematopoietic stem-cell transplantation in multiple sclerosis: a systematic review and meta-analysis

F Nabizadeh, K Pirahesh, N Rafiei, F Afrashteh… - Neurology and …, 2022 - Springer
Introduction In 1995, the use of autologous hematopoietic stem-cell transplantation
(AHSCT), which was previously used to treat hematological tumors, was introduced for …

Autologous haematopoietic stem cell transplantation and other cellular therapy in multiple sclerosis and immune-mediated neurological diseases: updated guidelines …

B Sharrack, R Saccardi, T Alexander… - Bone marrow …, 2020 - nature.com
These updated EBMT guidelines review the clinical evidence, registry activity and
mechanisms of action of haematopoietic stem cell transplantation (HSCT) in multiple …

Autologous hematopoietic stem cell transplantation in multiple sclerosis: a meta-analysis

MP Sormani, PA Muraro, I Schiavetti, A Signori… - Neurology, 2017 - AAN Enterprises
Objective: To summarize the evidence on immunoablative therapy followed by autologous
hematopoietic stem cell transplantation (aHSCT) to manage severe and treatment-refractory …

Haematopoietic SCT in severe autoimmune diseases: updated guidelines of the European Group for Blood and Marrow Transplantation

JA Snowden, R Saccardi, M Allez… - Bone marrow …, 2012 - nature.com
In 1997, the first consensus guidelines for haematopoietic SCT (HSCT) in autoimmune
diseases (ADs) were published, while an international coordinated clinical programme was …

The current standing of autologous haematopoietic stem cell transplantation for the treatment of multiple sclerosis

AG Willison, T Ruck, G Lenz, HP Hartung… - Journal of neurology, 2022 - Springer
Autologous haematopoietic stem cell transplantation (aHSCT) is gaining traction as a
valuable treatment option for patients affected by severe multiple sclerosis (MS), particularly …

Autologous hematopoietic SCT normalizes miR-16,-155 and-142-3p expression in multiple sclerosis patients

LCM Arruda, JCC Lorenzi, APA Sousa… - Bone marrow …, 2015 - nature.com
Autologous hematopoietic SCT (AHSCT) has been investigated in the past as a therapeutic
alternative for multiple sclerosis (MS). Despite advances in clinical management, knowledge …

Stem cell-based therapies for multiple sclerosis: current perspectives

FX Cuascut, GJ Hutton - Biomedicines, 2019 - mdpi.com
Multiple sclerosis (MS) is an inflammatory and neurodegenerative autoimmune disease of
the central nervous system (CNS). Disease-modifying therapies (DMT) targeting …

Immunological correlates of favorable long-term clinical outcome in multiple sclerosis patients after autologous hematopoietic stem cell transplantation

LCM Arruda, JTC de Azevedo, GLV de Oliveira… - Clinical …, 2016 - Elsevier
High dose immunosuppression followed by autologous hematopoietic stem cell
transplantation (AHSCT) induces prolonged clinical remission in multiple sclerosis (MS) …

Long-term outcomes of autologous hematopoietic stem cell transplantation with reduced-intensity conditioning in multiple sclerosis: physician's and patient's …

JL Shevchenko, AN Kuznetsov, TI Ionova… - Annals of …, 2015 - Springer
High-dose immunosuppressive therapy (HDIT) with autologous hematopoietic stem cell
transplantation (AHSCT) is a promising approach to treatment of multiple sclerosis (MS) …