[HTML][HTML] Looking for Novelty in an “Old” Receptor: Recent Advances Toward Our Understanding of GABAARs and Their Implications in Receptor Pharmacology
Diverse populations of GABAA receptors (GABAARs) throughout the brain mediate fast
inhibitory transmission and are modulated by various endogenous ligands and therapeutic …
inhibitory transmission and are modulated by various endogenous ligands and therapeutic …
[HTML][HTML] Brexanolone, a neurosteroid antidepressant, vindicates the GABAergic deficit hypothesis of depression and may foster resilience
B Lüscher, H Möhler - F1000Research, 2019 - ncbi.nlm.nih.gov
The GABAergic deficit hypothesis of depression states that a deficit of GABAergic
transmission in defined neural circuits is causal for depression. Conversely, an …
transmission in defined neural circuits is causal for depression. Conversely, an …
Advances in pharmacotherapy for postpartum depression: a structured review of standard-of-care antidepressants and novel neuroactive steroid antidepressants
Y Kaufman, SV Carlini… - Therapeutic Advances …, 2022 - journals.sagepub.com
Postpartum depression is one of the most common morbidities of childbearing, yet it is
underdiagnosed and undertreated with negative consequences for mother and offspring …
underdiagnosed and undertreated with negative consequences for mother and offspring …
GABAAR isoform and subunit structural motifs determine synaptic and extrasynaptic receptor localisation
Abstract GABA A receptors (GABA A Rs) are the principal inhibitory neurotransmitter
receptors in the central nervous system. They control neuronal excitability by synaptic and …
receptors in the central nervous system. They control neuronal excitability by synaptic and …
Relating neurosteroid modulation of inhibitory neurotransmission to behaviour
D Belelli, GD Phillips, JR Atack… - Journal of …, 2022 - Wiley Online Library
Studies in the 1980s revealed endogenous metabolites of progesterone and
deoxycorticosterone to be potent, efficacious, positive allosteric modulators (PAMs) of the …
deoxycorticosterone to be potent, efficacious, positive allosteric modulators (PAMs) of the …
[HTML][HTML] Functional alternatives to alcohol
DJ Nutt, RJ Tyacke, M Spriggs, V Jacoby, AD Borthwick… - Nutrients, 2022 - mdpi.com
The consumption of alcohol is associated with well-known health harms and many
governments worldwide are actively engaged in devising approaches to reduce them. To …
governments worldwide are actively engaged in devising approaches to reduce them. To …
[HTML][HTML] Tonic GABAA receptor-mediated currents of human cortical GABAergic interneurons vary amongst cell types
M Field, IP Lukacs, E Hunter, R Stacey… - Journal of …, 2021 - Soc Neuroscience
Persistent anion conductances through GABA A receptors (GABA A Rs) are important
modulators of neuronal excitability. However, it is currently unknown how the amplitudes of …
modulators of neuronal excitability. However, it is currently unknown how the amplitudes of …
[HTML][HTML] The immediate and maintained effects of neurosteroids on GABAA receptors
D Belelli, JA Peters, GD Phillips, JJ Lambert - Current Opinion in Endocrine …, 2022 - Elsevier
Allopregnanolone is an endogenous neurosteroid that acts in a rapid non-genomic manner
to enhance the function of the GABA A receptor (GABA AR), the major inhibitory receptor in …
to enhance the function of the GABA A receptor (GABA AR), the major inhibitory receptor in …
[HTML][HTML] Neurosteroid Modulation of Synaptic and Extrasynaptic GABAA Receptors of the Mouse Nucleus Accumbens
SJ Mitchell, GD Phillips, B Tench, Y Li, D Belelli… - Biomolecules, 2024 - mdpi.com
The recent approval of formulations of the endogenous neurosteroid allopregnanolone
(brexanolone) and the synthetic neuroactive steroid SAGE-217 (zuranolone) to treat …
(brexanolone) and the synthetic neuroactive steroid SAGE-217 (zuranolone) to treat …
Reducing the harms of alcohol: nutritional interventions and functional alcohol alternatives.
The health risks and harm associated with regular alcohol consumption are well
documented. In a recent WHO statement published in The Lancet Public Health alcohol …
documented. In a recent WHO statement published in The Lancet Public Health alcohol …