Diverse populations of GABAA receptors (GABAARs) throughout the brain mediate fast
inhibitory transmission and are modulated by various endogenous ligands and therapeutic …

The GABAergic deficit hypothesis of depression states that a deficit of GABAergic
transmission in defined neural circuits is causal for depression. Conversely, an …

Postpartum depression is one of the most common morbidities of childbearing, yet it is
underdiagnosed and undertreated with negative consequences for mother and offspring …

Abstract GABA A receptors (GABA A Rs) are the principal inhibitory neurotransmitter
receptors in the central nervous system. They control neuronal excitability by synaptic and …

Studies in the 1980s revealed endogenous metabolites of progesterone and
deoxycorticosterone to be potent, efficacious, positive allosteric modulators (PAMs) of the …

The consumption of alcohol is associated with well-known health harms and many
governments worldwide are actively engaged in devising approaches to reduce them. To …

Persistent anion conductances through GABA A receptors (GABA A Rs) are important
modulators of neuronal excitability. However, it is currently unknown how the amplitudes of …

Allopregnanolone is an endogenous neurosteroid that acts in a rapid non-genomic manner
to enhance the function of the GABA A receptor (GABA AR), the major inhibitory receptor in …

The recent approval of formulations of the endogenous neurosteroid allopregnanolone
(brexanolone) and the synthetic neuroactive steroid SAGE-217 (zuranolone) to treat …

The health risks and harm associated with regular alcohol consumption are well
documented. In a recent WHO statement published in The Lancet Public Health alcohol …