Methylation of cytosine bases in DNA provides a layer of epigenetic control in many
eukaryotes that has important implications for normal biology and disease. Therefore …

DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors.
However, for several decades after its independent discovery by two laboratories in 1983, it …

Background: DNA N6-methyladenine plays an important role in the restriction-modification
system to isolate invasion from adventive DNA. The shortcomings of the high time …

Mitotic cell division increases tumour mutation burden and copy number load, predictive
markers of the clinical benefit of immunotherapy. Cell division correlates also with genomic …

Cell lines are invaluable biomedical research tools, and recent literature has emphasized
the importance of genotype authentication and characterization. In the present study, 24 out …

Background Immune checkpoint inhibitors (ICIs) have modest activity in ovarian cancer
(OC). To augment their activity, we used priming with the hypomethylating agent …

Tissue specific patterns of methylated cytosine residues vary with age, can be altered by
environmental factors, and are often abnormal in human disease yet the cellular …

Aberrant DNA methylation of CpG islands has been widely observed in human colorectal
tumors and is associated with gene silencing when it occurs in promoter areas. A subset of …

Epigenetics investigates heritable changes in gene expression that occur without changes
in DNA sequence. Several epigenetic mechanisms, including DNA methylation and histone …

Every year more than 13 million deaths worldwide are due to environmental pollutants, and
approximately 24% of diseases are caused by environmental exposures that might be …