Ischaemic stroke involves the rapid onset of focal neurological dysfunction, most commonly
due to an arterial blockage in a specific region of the brain. Stroke is a leading cause of …

Chronic psychosocial stress is increasingly recognized as a risk factor for late-onset
Alzheimer's disease (LOAD) and associated cognitive deficits. Chronic stress also primes …

Microglia are the immune cells of the brain, involved in synapse formation, circuit sculpting,
myelination, plasticity, and cognition. Being active players during early development as well …

Experimental stroke leads to microglia activation and progressive neuronal loss at sites of
secondary neurodegeneration (SND). These lesions are remote from, but synaptically …

After stroke, there is a rapid necrosis of all cells in the infarct, followed by a delayed loss of
neurons both in brain areas surrounding the infarct, known as 'selective neuronal loss', and …

Background and Purpose: Stroke disrupts neuronal functions in both local and remotely
connected regions, leading to network-wide deficits that can hinder recovery. The thalamus …

Stress, which refers to a combination of physiological, neuroendocrine, behavioral, and
emotional responses to novel or threatening stimuli, is essentially a defensive adaptation …

It has recently been identified that after motor cortex stroke, the ability of microglia processes
to respond to local damage cues is lost from the thalamus, a major site of secondary …

Dendritic cells (DCs) are professional antigen presenting cells that constantly survey the
environment acting as sentinels of the immune system, including in the CNS. DCs are …

Background Pathomechanism of secondary degeneration in remote regions after ischemic
stroke has not been totally clarified. Contrast-enhanced MRI with injecting Gd-DTPA in …