Over the past decade, remarkable advances have been witnessed in the development of
small-molecule probes. These molecular tools have been widely applied for interrogating …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that primarily affects
elderly people and constitutes a major source of disability worldwide. Notably, the …

In medical imaging, techniques such as magnetic resonance imaging, contrast-enhanced
computerized tomography, and positron emission tomography (PET) are extensively …

Central nervous system (CNS) drug discovery suffers from high attrition rates; translational
neuroscience approaches aiming to reduce these high rates include the use of brain …

Aryl fluorides are expected to be useful as radiolabeling precursors due to their chemical
stability and ready availability. However, direct radiolabeling via carbon‐fluorine (C− F) …

Herein, we report a photoredox nucleophilic (radio) fluorination using TEMPO-derived
alkoxyamines, a class of substrates accessible in a single step from a diversity of readily …

Positron emission tomography (PET) and fluorescent imaging play a pivotal role in medical
diagnosis, biomedical oncologic research, and drug development process, which include …

The emergence of tumor-associated human carbonic anhydrases (hCA) as promising
therapeutic targets has urged rigorous research into the development of potent and selective …

The difluoromethyl functionality has proven useful in drug discovery, as it can modulate the
properties of bioactive molecules. For PET imaging, this structural motif has been largely …

Positron emission tomography (PET) can be used as a noninvasive method to longitudinally
monitor and quantify the expression of proteins in the brain in vivo. It can be used to monitor …