Nonspecific binding—fundamental concepts and consequences for biosensing applications
A Frutiger, A Tanno, S Hwu, RF Tiefenauer… - Chemical …, 2021 - ACS Publications
Nature achieves differentiation of specific and nonspecific binding in molecular interactions
through precise control of biomolecules in space and time. Artificial systems such as …
through precise control of biomolecules in space and time. Artificial systems such as …
Structure, dynamics, assembly, and evolution of protein complexes
JA Marsh, SA Teichmann - Annual review of biochemistry, 2015 - annualreviews.org
The assembly of individual proteins into functional complexes is fundamental to nearly all
biological processes. In recent decades, many thousands of homomeric and heteromeric …
biological processes. In recent decades, many thousands of homomeric and heteromeric …
Determinants of the rate of protein sequence evolution
The rate and mechanism of protein sequence evolution have been central questions in
evolutionary biology since the 1960s. Although the rate of protein sequence evolution …
evolutionary biology since the 1960s. Although the rate of protein sequence evolution …
Exploring the costs of horizontal gene transfer
DA Baltrus - Trends in ecology & evolution, 2013 - cell.com
Horizontal gene transfer (HGT) is one of the most important evolutionary forces within
microbial populations. Although evidence for beneficial fitness effects of HGT is …
microbial populations. Although evidence for beneficial fitness effects of HGT is …
The protein folding problem: the role of theory
The protein folding problem was first articulated as question of how order arose from
disorder in proteins: How did the various native structures of proteins arise from interatomic …
disorder in proteins: How did the various native structures of proteins arise from interatomic …
Causes of evolutionary rate variation among protein sites
It has long been recognized that certain sites within a protein, such as sites in the protein
core or catalytic residues in enzymes, are evolutionarily more conserved than other sites …
core or catalytic residues in enzymes, are evolutionarily more conserved than other sites …
Weak chemical interactions that drive protein evolution: crowding, sticking, and quinary structure in folding and function
D Guin, M Gruebele - Chemical reviews, 2019 - ACS Publications
In recent years, better instrumentation and greater computing power have enabled the
imaging of elusive biomolecule dynamics in cells, driving many advances in understanding …
imaging of elusive biomolecule dynamics in cells, driving many advances in understanding …
Biophysics of protein evolution and evolutionary protein biophysics
The study of molecular evolution at the level of protein-coding genes often entails comparing
large datasets of sequences to infer their evolutionary relationships. Despite the importance …
large datasets of sequences to infer their evolutionary relationships. Despite the importance …
Residue mutations and their impact on protein structure and function: detecting beneficial and pathogenic changes
The present review focuses on the evolution of proteins and the impact of amino acid
mutations on function from a structural perspective. Proteins evolve under the law of natural …
mutations on function from a structural perspective. Proteins evolve under the law of natural …
Mechanisms of protein evolution
How do proteins evolve? How do changes in sequence mediate changes in protein
structure, and in turn in function? This question has multiple angles, ranging from …
structure, and in turn in function? This question has multiple angles, ranging from …