Caspases are an evolutionary conserved family of cysteine proteases that are centrally
involved in cell death and inflammation responses. A wealth of foundational insight into the …

Inflammation is part of the non-specific immune response that occurs in reaction to any type
of bodily injury. In some disorders, the inflammatory process− which under normal …

Missense mutations in the CIAS1 gene cause three autoinflammatory disorders: familial cold
autoinflammatory syndrome, Muckle–Wells syndrome and neonatal-onset multiple-system …

Caspases, a family of evolutionarily, conserved cysteinyl proteases, mediate both apoptosis
and inflammation through aspartate-specific cleavage of a wide number of cellular …

Cryopyrin is essential for caspase-1 activation triggered by Toll-like receptor (TLR) ligands
in the presence of adenosine triphosphate (ATP). However, the events linking bacterial …

Regulated cell death is an integral part of life, and has broad effects on organism
development and homeostasis. Malfunctions within the regulated cell death process …

The aspartate-specific cysteine protease caspase-1 is activated by the inflammasomes and
is responsible for the proteolytic maturation of the cytokines IL-1β and IL-18 during infection …

Caspase-1 plays a fundamental role in innate immunity and in several important
inflammatory diseases as the protease activates the pro-inflammatory cytokines proIL-1β …

The Toll-interleukin-1 Receptor (TIR) domain-containing adaptor protein (TIRAP) represents
a key intracellular signalling molecule regulating diverse immune responses. Its capacity to …

Caspases are a family of cysteine proteases expressed as inactive zymogens in virtually all
animal cells. These enzymes play a central role in most cell death pathways leading to …